Lepuron
Lepuron Brand names, Lepuron Analogs
Lepuron Brand Names Mixture
- No information avaliable
Lepuron Chemical_Formula
C16H20FN3O4
Lepuron RX_link
http://www.rxlist.com/cgi/generic3/linezolid.htm
Lepuron fda sheet
Lepuron msds (material safety sheet)
Lepuron Synthesis Reference
No information avaliable
Lepuron Molecular Weight
337.346 g/mol
Lepuron Melting Point
No information avaliable
Lepuron H2O Solubility
3 mg/mL
Lepuron State
Solid
Lepuron LogP
0.232
Lepuron Dosage Forms
Solution; Tablets
Lepuron Indication
For the treatment of bacterial infections caused by susceptible strains of vancomycin resistant Enterococcus faecium, Staphylococcal aureus (methicillin resistant and susceptible strains), Streptococcus pneumoniae, Streptococcus pyogenes, Streptococcus agalactiae.
Lepuron Pharmacology
Linezolid is a synthetic antibacterial agent of a new class of antibiotics, the oxazolidinones, which has clinical utility in the treatment of infections caused by aerobic Gram-positive bacteria. The in vitro spectrum of activity of linezolid also includes certain Gram-negative bacteria and anaerobic bacteria. Susceptible organisms include methicillin- and vancomycin-resistant staphylococci, vancomycin-resistant enterococci, penicillin-resistant pneumococci and anaerobes. Oxazolidinones inhibit protein synthesis by binding at the P site at the ribosomal 50S subunit. Resistance to other protein synthesis inhibitors does not affect oxazolidinone activity, however rare development of oxazolidinone resistance cases, associated with 23S rRNA alterations during treatment have been reported. Linezolid inhibits bacterial protein synthesis through a mechanism of action different from that of other antibacterial agents; therefore, cross-resistance between linezolid and other classes of antibiotics is unlikely.
Lepuron Absorption
Linezolid is rapidly and extensively absorbed after oral dosing. Maximum plasma concentrations are reached approximately 1 to 2 hours after dosing, and the absolute bioavailability is approximately 100%.
Lepuron side effects and Toxicity
Clinical signs of acute toxicity lead to decreased activity, ataxia, vomiting and tremors.
Lepuron Patient Information
Lepuron Organisms Affected
Gram negative and gram positive bacteria
