Ismelin
Ismelin Brand names, Ismelin Analogs
Ismelin Brand Names Mixture
- No information avaliable
Ismelin Chemical_Formula
C10H22N4
Ismelin RX_link
No information avaliable
Ismelin fda sheet
Ismelin msds (material safety sheet)
Ismelin Synthesis Reference
No information avaliable
Ismelin Molecular Weight
198.309 g/mol
Ismelin Melting Point
250 oC (sulfate salt)
Ismelin H2O Solubility
Very soluble
Ismelin State
Solid
Ismelin LogP
0.693
Ismelin Dosage Forms
Tablet
Ismelin Indication
For the treatment of moderate and severe hypertension, either alone or as an adjunct, and for the treatment of renal hypertension.
Ismelin Pharmacology
High blood pressure can cause the heart and arteries to not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled. Guanethidine works by decreasing the heart rate and relaxing the blood vessels so that blood can flow more easily through the body, thereby reducing these risks. It is a postganglionic sympathetic nerve terminal blocker that prevents the release of norepinephrine from nerve terminals.
Ismelin Absorption
3-30% of oral dose (poor and highly variable)
Ismelin side effects and Toxicity
Side effects include drowsiness, dizziness, tiredness or confusion. LD50=1000 mg/kg (mouse, oral)
Ismelin Patient Information
http://www.drugs.com/cons/Guanadrel.html
Ismelin Organisms Affected
Humans and other mammals
