Ibutilidum [INN-Latin]
Brand names,
Ibutilidum [INN-Latin]
Analogs
Ibutilidum [INN-Latin]
Brand Names Mixture
Ibutilidum [INN-Latin]
Chemical_Formula
C20H36N2O3S
Ibutilidum [INN-Latin]
RX_link
http://www.rxlist.com/cgi/generic3/ibutilide.htm
Ibutilidum [INN-Latin]
fda sheet
Ibutilidum [INN-Latin]
msds (material safety sheet)
Ibutilidum [INN-Latin]
Synthesis Reference
No information avaliable
Ibutilidum [INN-Latin]
Molecular Weight
384.578 g/mol
Ibutilidum [INN-Latin]
Melting Point
No information avaliable
Ibutilidum [INN-Latin]
H2O Solubility
100 mg/mL
Ibutilidum [INN-Latin]
State
Solid
Ibutilidum [INN-Latin]
LogP
5.756
Ibutilidum [INN-Latin]
Dosage Forms
Solution (for injection); Suspension
Ibutilidum [INN-Latin]
Indication
Indicated for the rapid conversion of atrial fibrillation or atrial flutter of recent onset to sinus rhythm.
Ibutilidum [INN-Latin]
Pharmacology
Ibutilide fumurate prolongs the action potential duration and increases both atrial and ventricular refractoriness in vivo, i.e., class III electrophysiologic effects. Voltage clamp studies indicate that Ibutilide, at nanomolar concentrations, delays repolarization by activation of a slow, inward current (predominantly sodium), rather than by blocking outward potassium currents, which is the mechanism by which most other class III antiarrhythmics act.
Ibutilidum [INN-Latin]
Absorption
Rapid after intravenous injection
Ibutilidum [INN-Latin]
side effects and Toxicity
No information avaliable
Ibutilidum [INN-Latin]
Patient Information
No information avaliable
Ibutilidum [INN-Latin]
Organisms Affected
Humans and other mammals