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Brand names,
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Analogs
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Brand Names Mixture
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Chemical_Formula
C20H36N2O3S
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RX_link
http://www.rxlist.com/cgi/generic3/ibutilide.htm
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fda sheet
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msds (material safety sheet)
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Synthesis Reference
No information avaliable
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Molecular Weight
384.578 g/mol
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Melting Point
No information avaliable
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H2O Solubility
100 mg/mL
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State
Solid
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LogP
5.756
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Dosage Forms
Solution (for injection); Suspension
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Indication
Indicated for the rapid conversion of atrial fibrillation or atrial flutter of recent onset to sinus rhythm.
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Pharmacology
Ibutilide fumurate prolongs the action potential duration and increases both atrial and ventricular refractoriness in vivo, i.e., class III electrophysiologic effects. Voltage clamp studies indicate that Ibutilide, at nanomolar concentrations, delays repolarization by activation of a slow, inward current (predominantly sodium), rather than by blocking outward potassium currents, which is the mechanism by which most other class III antiarrhythmics act.
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Absorption
Rapid after intravenous injection
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side effects and Toxicity
No information avaliable
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Patient Information
No information avaliable
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Organisms Affected
Humans and other mammals