Ibutilida [INN-Spanish]
Brand names,
Ibutilida [INN-Spanish]
Analogs
Ibutilida [INN-Spanish]
Brand Names Mixture
Ibutilida [INN-Spanish]
Chemical_Formula
C20H36N2O3S
Ibutilida [INN-Spanish]
RX_link
http://www.rxlist.com/cgi/generic3/ibutilide.htm
Ibutilida [INN-Spanish]
fda sheet
Ibutilida [INN-Spanish]
msds (material safety sheet)
Ibutilida [INN-Spanish]
Synthesis Reference
No information avaliable
Ibutilida [INN-Spanish]
Molecular Weight
384.578 g/mol
Ibutilida [INN-Spanish]
Melting Point
No information avaliable
Ibutilida [INN-Spanish]
H2O Solubility
100 mg/mL
Ibutilida [INN-Spanish]
State
Solid
Ibutilida [INN-Spanish]
LogP
5.756
Ibutilida [INN-Spanish]
Dosage Forms
Solution (for injection); Suspension
Ibutilida [INN-Spanish]
Indication
Indicated for the rapid conversion of atrial fibrillation or atrial flutter of recent onset to sinus rhythm.
Ibutilida [INN-Spanish]
Pharmacology
Ibutilide fumurate prolongs the action potential duration and increases both atrial and ventricular refractoriness in vivo, i.e., class III electrophysiologic effects. Voltage clamp studies indicate that Ibutilide, at nanomolar concentrations, delays repolarization by activation of a slow, inward current (predominantly sodium), rather than by blocking outward potassium currents, which is the mechanism by which most other class III antiarrhythmics act.
Ibutilida [INN-Spanish]
Absorption
Rapid after intravenous injection
Ibutilida [INN-Spanish]
side effects and Toxicity
No information avaliable
Ibutilida [INN-Spanish]
Patient Information
No information avaliable
Ibutilida [INN-Spanish]
Organisms Affected
Humans and other mammals