Heparin Cy 216
Brand names,
Heparin Cy 216
Analogs
Heparin Cy 216
Brand Names Mixture
Heparin Cy 216
Chemical_Formula
(C26H40N2O36S5)n
Heparin Cy 216
RX_link
http://www.rxlist.com/cgi/generic/heparin.htm
Heparin Cy 216
fda sheet
Heparin Cy 216
msds (material safety sheet)
Heparin Cy 216
Synthesis Reference
No information avaliable
Heparin Cy 216
Molecular Weight
12000-15000 g/mol
Heparin Cy 216
Melting Point
No information avaliable
Heparin Cy 216
H2O Solubility
Soluble
Heparin Cy 216
State
Solid
Heparin Cy 216
LogP
No information avaliable
Heparin Cy 216
Dosage Forms
Solution for subcutaneous injection; Intravenous injection; Intravenous infusion
Heparin Cy 216
Indication
For anticoagulant therapy in prophylaxis and treatment of venous thrombosis and its extension, for prevention of post-operative deep venous thrombosis and pulmonary embolism and for the prevention of clotting in arterial and cardiac surgery.
Heparin Cy 216
Pharmacology
Heparin is a highly acidic mucopolysaccharide formed of equal parts of sulfated D-glucosamine and D-glucuronic acid with sulfaminic bridges. The molecular weight ranges from six to twenty thousand. Heparin occurs in and is obtained from liver, lung, mast cells, etc., of vertebrates. Heparin is a well known and commonly used anticoagulant which has antithrombotic properties. Heparin is indicated for the prophylaxis of deep vein thrombosis, which may lead to pulmonary embolism, and also for the prophylaxis of ischemic complications of unstable angina and non-Q-wave myocardial infarction, when concurrently administered with aspirin. Heparin inhibits reactions that lead to the clotting of blood and the formation of fibrin clots both in vitro and in vivo. Heparin acts at multiple sites in the normal coagulation system. Small amounts of Heparin in combination with antithrombin III (Heparin cofactor) can inhibit thrombosis by inactivating activated Factor X and inhibiting the conversion of prothrombin to thrombin. Once active thrombosis has developed, larger amounts of heparin can inhibit further coagulation by inactivating thrombin and preventing the conversion of fibrinogen to fibrin. Heparin also prevents the formation of a stable fibrin clot by inhibiting the activation of the fibrin stabilizing factor.
Heparin Cy 216
Absorption
Some oral absorption but lack of anticoagulant effect. Rapidly taken up by endothelial cells with remainder bound to plasma proteins.
Heparin Cy 216
side effects and Toxicity
Heparin sodium - Mouse, median lethal dose greater than 5000 mg/kg. Another side effect is heparin induced thrombocytopenia (HIT syndrome). HIT is caused by an immunological reaction that makes platelets form clots within the blood vessels, thereby using up coagulation factors
Heparin Cy 216
Patient Information
No information avaliable
Heparin Cy 216
Organisms Affected
Humans and other mammals