Calcilean
Calcilean Brand names, Calcilean Analogs
- Alpha-Heparin
- Ariven
- Arteven
- Bemiparin
- Calcilean
- Calciparine
- Certoparin
- Clexane
- Clivarin
- Clivarine
- Dalteparin
- Depo-Heparin
- Enoxaparin
- Enoxaparin sodium
- Eparina [DCIT]
- Fluxum
- Fragmin A
- Fragmin B
- Fraxiparin
- Hed-Heparin
- Hepalean
- Heparin Cy 216
- Heparin Leo
- Heparin Lock Flush
- Heparin sodium
- Heparin sodium preservative Free
- Heparin sodium salt
- Heparin sulfate
- Heparinate
- Heparinic acid
- Hepathrom
- Leparan
- Lipo-Hepin
- Liquaemin
- Liquaemin Sodium
- Liquemin
- Low molecular weight heparin sodium
- Multiparin
- Novoheparin
- Pabyrin
- Parnaparin
- Parvoparin
- Pularin
- Reviparin
- Sandoparin
- Sodium heparin
- Sublingula
- Thromboliquine
- Vetren
- Vitrum AB
Calcilean Brand Names Mixture
- No information avaliable
Calcilean Chemical_Formula
(C26H40N2O36S5)n
Calcilean RX_link
http://www.rxlist.com/cgi/generic/heparin.htm
Calcilean fda sheet
Calcilean msds (material safety sheet)
Calcilean Synthesis Reference
No information avaliable
Calcilean Molecular Weight
12000-15000 g/mol
Calcilean Melting Point
No information avaliable
Calcilean H2O Solubility
Soluble
Calcilean State
Solid
Calcilean LogP
No information avaliable
Calcilean Dosage Forms
Solution for subcutaneous injection; Intravenous injection; Intravenous infusion
Calcilean Indication
For anticoagulant therapy in prophylaxis and treatment of venous thrombosis and its extension, for prevention of post-operative deep venous thrombosis and pulmonary embolism and for the prevention of clotting in arterial and cardiac surgery.
Calcilean Pharmacology
Heparin is a highly acidic mucopolysaccharide formed of equal parts of sulfated D-glucosamine and D-glucuronic acid with sulfaminic bridges. The molecular weight ranges from six to twenty thousand. Heparin occurs in and is obtained from liver, lung, mast cells, etc., of vertebrates. Heparin is a well known and commonly used anticoagulant which has antithrombotic properties. Heparin is indicated for the prophylaxis of deep vein thrombosis, which may lead to pulmonary embolism, and also for the prophylaxis of ischemic complications of unstable angina and non-Q-wave myocardial infarction, when concurrently administered with aspirin. Heparin inhibits reactions that lead to the clotting of blood and the formation of fibrin clots both in vitro and in vivo. Heparin acts at multiple sites in the normal coagulation system. Small amounts of Heparin in combination with antithrombin III (Heparin cofactor) can inhibit thrombosis by inactivating activated Factor X and inhibiting the conversion of prothrombin to thrombin. Once active thrombosis has developed, larger amounts of heparin can inhibit further coagulation by inactivating thrombin and preventing the conversion of fibrinogen to fibrin. Heparin also prevents the formation of a stable fibrin clot by inhibiting the activation of the fibrin stabilizing factor.
Calcilean Absorption
Some oral absorption but lack of anticoagulant effect. Rapidly taken up by endothelial cells with remainder bound to plasma proteins.
Calcilean side effects and Toxicity
Heparin sodium - Mouse, median lethal dose greater than 5000 mg/kg. Another side effect is heparin induced thrombocytopenia (HIT syndrome). HIT is caused by an immunological reaction that makes platelets form clots within the blood vessels, thereby using up coagulation factors
Calcilean Patient Information
No information avaliable
Calcilean Organisms Affected
Humans and other mammals
