Multiparin
Brand names,
Multiparin
Analogs
Multiparin
Brand Names Mixture
Multiparin
Chemical_Formula
(C26H40N2O36S5)n
Multiparin
RX_link
http://www.rxlist.com/cgi/generic/heparin.htm
Multiparin
fda sheet
Multiparin
msds (material safety sheet)
Multiparin
Synthesis Reference
No information avaliable
Multiparin
Molecular Weight
12000-15000 g/mol
Multiparin
Melting Point
No information avaliable
Multiparin
H2O Solubility
Soluble
Multiparin
State
Solid
Multiparin
LogP
No information avaliable
Multiparin
Dosage Forms
Solution for subcutaneous injection; Intravenous injection; Intravenous infusion
Multiparin
Indication
For anticoagulant therapy in prophylaxis and treatment of venous thrombosis and its extension, for prevention of post-operative deep venous thrombosis and pulmonary embolism and for the prevention of clotting in arterial and cardiac surgery.
Multiparin
Pharmacology
Heparin is a highly acidic mucopolysaccharide formed of equal parts of sulfated D-glucosamine and D-glucuronic acid with sulfaminic bridges. The molecular weight ranges from six to twenty thousand. Heparin occurs in and is obtained from liver, lung, mast cells, etc., of vertebrates. Heparin is a well known and commonly used anticoagulant which has antithrombotic properties. Heparin is indicated for the prophylaxis of deep vein thrombosis, which may lead to pulmonary embolism, and also for the prophylaxis of ischemic complications of unstable angina and non-Q-wave myocardial infarction, when concurrently administered with aspirin. Heparin inhibits reactions that lead to the clotting of blood and the formation of fibrin clots both in vitro and in vivo. Heparin acts at multiple sites in the normal coagulation system. Small amounts of Heparin in combination with antithrombin III (Heparin cofactor) can inhibit thrombosis by inactivating activated Factor X and inhibiting the conversion of prothrombin to thrombin. Once active thrombosis has developed, larger amounts of heparin can inhibit further coagulation by inactivating thrombin and preventing the conversion of fibrinogen to fibrin. Heparin also prevents the formation of a stable fibrin clot by inhibiting the activation of the fibrin stabilizing factor.
Multiparin
Absorption
Some oral absorption but lack of anticoagulant effect. Rapidly taken up by endothelial cells with remainder bound to plasma proteins.
Multiparin
side effects and Toxicity
Heparin sodium - Mouse, median lethal dose greater than 5000 mg/kg. Another side effect is heparin induced thrombocytopenia (HIT syndrome). HIT is caused by an immunological reaction that makes platelets form clots within the blood vessels, thereby using up coagulation factors
Multiparin
Patient Information
No information avaliable
Multiparin
Organisms Affected
Humans and other mammals