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Brand names,
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Analogs
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Brand Names Mixture
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Chemical_Formula
C16H13ClN2O2
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RX_link
http://www.rxlist.com/cgi/generic/temaz.htm
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fda sheet
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msds (material safety sheet)
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Synthesis Reference
E. Reeder et al., U.S. Pat. 3,340,253 (1967)
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Molecular Weight
300.739 g/mol
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Melting Point
119-121oC
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H2O Solubility
164 mg/L
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State
Solid
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LogP
2.479
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Dosage Forms
Capsule (7.5 mg, 15 mg, and 30 mg)
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Indication
For the short-term treatment of insomnia (generally 7-10 days).
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Pharmacology
Temazepam is a benzodiazepine used as a hypnotic agent in the management of insomnia. Temazepam produces CNS depression at limbic, thalamic, and hypothalamic levels of the CNS. Temazepam increases the affinity of the neurotransmitter gamma-aminobutyric acid (GABA) for GABA receptors by binding to benzodiazepine receptors. Results are sedation, hypnosis, skeletal muscle relaxation, anticonvulsant activity, and anxiolytic action.
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Absorption
Well absorbed, minimal first-pass metabolism.
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side effects and Toxicity
No information avaliable
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Patient Information
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Organisms Affected
Humans and other mammals