Fluvoxamine maleate
Fluvoxamine maleate Brand names, Fluvoxamine maleate Analogs
Fluvoxamine maleate Brand Names Mixture
- No information avaliable
Fluvoxamine maleate Chemical_Formula
C15H21F3N2O2
Fluvoxamine maleate RX_link
http://www.rxlist.com/cgi/generic/fluvox.htm
Fluvoxamine maleate fda sheet
Fluvoxamine maleate msds (material safety sheet)
Fluvoxamine maleate Synthesis Reference
Neth. pat. Appl. 7503310; H. B. A. Welle, V. Classen, U.S. pat. 4085225
Fluvoxamine maleate Molecular Weight
318.335 g/mol
Fluvoxamine maleate Melting Point
120-122.5 oC
Fluvoxamine maleate H2O Solubility
No information avaliable
Fluvoxamine maleate State
Solid
Fluvoxamine maleate LogP
No information avaliable
Fluvoxamine maleate Dosage Forms
Tablet
Fluvoxamine maleate Indication
For treatment of depression and for Obsessive Compulsive Disorder (OCD)
Fluvoxamine maleate Pharmacology
Fluvoxamine is one of a class of antidepressants known as selective serotonin reuptake inhibitors (SSRIs). It is used to treat the depression associated with mood disorders. It is also used on occassion in the treatment of body dysmorphic disorder and anxiety. The antidepressant, antiobsessive-compulsive, and antibulimic actions of Fluvoxamine are presumed to be linked to its inhibition of CNS neuronal uptake of serotonin. In vitro studies show that Fluvoxamine is a potent and selective inhibitor of neuronal serotonin reuptake and has only very weak effects on norepinephrine and dopamine neuronal reuptake. Fluvoxamine has no significant affinity for adrenergic (alpha1, alpha2, beta), cholinergic, GABA, dopaminergic, histaminergic, serotonergic (5HT1A, 5HT1B, 5HT2), or benzodiazepine receptors; antagonism of such receptors has been hypothesized to be associated with various anticholinergic, sedative, and cardiovascular effects for other psychotropic drugs. The chronic administration of Fluvoxamine was found to downregulate brain norepinephrine receptors, as has been observed with other drugs effective in the treatment of major depressive disorder. Fluvoxamine does not inhibit monoamine oxidase.
Fluvoxamine maleate Absorption
Well absorbed, bioavailability of fluvoxamine maleate is 53%.
Fluvoxamine maleate side effects and Toxicity
Side effects include anorexia, constipation, dry mouth, headache, nausea, nervousness, skin rash, sleep problems, somnolence, liver toxicity, mania, increase urination, seizures, sweating increase, tremors, or Tourette's syndrome.
Fluvoxamine maleate Patient Information
No information avaliable
Fluvoxamine maleate Organisms Affected
Humans and other mammals
