Prazosin Base
Prazosin Base Brand names, Prazosin Base Analogs
Prazosin Base Brand Names Mixture
- No information avaliable
Prazosin Base Chemical_Formula
C19H21N5O4
Prazosin Base RX_link
http://www.rxlist.com/cgi/generic3/prazosin.htm
Prazosin Base fda sheet
Prazosin Base msds (material safety sheet)
Prazosin Base Synthesis Reference
No information avaliable
Prazosin Base Molecular Weight
383.401 g/mol
Prazosin Base Melting Point
279 oC
Prazosin Base H2O Solubility
0.2 mg/mL (as HCl salt)
Prazosin Base State
Solid
Prazosin Base LogP
0.934
Prazosin Base Dosage Forms
Tablet
Prazosin Base Indication
For treatment of hypertension and chronic heart failure.
Prazosin Base Pharmacology
Prazosin is an alpha-adrenergic blocking agent used to treat hypertension and benign prostatic hyperplasia. Accordingly, Prazosin is a selective inhibitor of the alpha1 subtype of alpha adrenergic receptors. In the human prostate, Prazosin antagonizes phenylephrine (alpha1 agonist)-induced contractions, in vitro, and binds with high affinity to the alpha1c adrenoceptor, which is thought to be the predominant functional type in the prostate. Studies in normal human subjects have shown that Prazosin competitively antagonized the pressor effects of phenylephrine (an alpha1 agonist) and the systolic pressor effect of norepinephrine. The antihypertensive effect of Prazosin results from a decrease in systemic vascular resistance and the parent compound Prazosin is primarily responsible for the antihypertensive activity.
Prazosin Base Absorption
Well-absorbed from gastrointestinal tract; bioavailability is variable (50 to 85%).
Prazosin Base side effects and Toxicity
No information avaliable
Prazosin Base Patient Information
Dizziness or drowsiness may occur after the first dose of this medicine. Avoid driving or performing hazardous tasks for the first 24 hours after taking this medicine or when the dose is increased. Dizziness, light-headedness or fainting may occur, especially when rising from a lying or sitting position. Getting up slowly may help lessen the problem. These effects may also occur if you drink alcohol, stand for long periods of time, exercise, or if the weather is hot. While taking prazosin HCl, be careful in the amount of alcohol you drink. Also, use extra care during exercise or hot weather, or if standing for long periods. Check with your physician if you have any questions.
Prazosin Base Organisms Affected
Humans and other mammals
