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Prazosin HCl Brand names, Prazosin HCl Analogs

Prazosin HCl Brand Names Mixture

  • No information avaliable

Prazosin HCl Chemical_Formula

C19H21N5O4

Prazosin HCl RX_link

http://www.rxlist.com/cgi/generic3/prazosin.htm

Prazosin HCl fda sheet

Prazosin HCl msds (material safety sheet)

Prazosin_HCl MSDS

Prazosin HCl Synthesis Reference

No information avaliable

Prazosin HCl Molecular Weight

383.401 g/mol

Prazosin HCl Melting Point

279 oC

Prazosin HCl H2O Solubility

0.2 mg/mL (as HCl salt)

Prazosin HCl State

Solid

Prazosin HCl LogP

0.934

Prazosin HCl Dosage Forms

Tablet

Prazosin HCl Indication

For treatment of hypertension and chronic heart failure.

Prazosin HCl Pharmacology

Prazosin is an alpha-adrenergic blocking agent used to treat hypertension and benign prostatic hyperplasia. Accordingly, Prazosin is a selective inhibitor of the alpha1 subtype of alpha adrenergic receptors. In the human prostate, Prazosin antagonizes phenylephrine (alpha1 agonist)-induced contractions, in vitro, and binds with high affinity to the alpha1c adrenoceptor, which is thought to be the predominant functional type in the prostate. Studies in normal human subjects have shown that Prazosin competitively antagonized the pressor effects of phenylephrine (an alpha1 agonist) and the systolic pressor effect of norepinephrine. The antihypertensive effect of Prazosin results from a decrease in systemic vascular resistance and the parent compound Prazosin is primarily responsible for the antihypertensive activity.

Prazosin HCl Absorption

Well-absorbed from gastrointestinal tract; bioavailability is variable (50 to 85%).

Prazosin HCl side effects and Toxicity

No information avaliable

Prazosin HCl Patient Information

Dizziness or drowsiness may occur after the first dose of this medicine. Avoid driving or performing hazardous tasks for the first 24 hours after taking this medicine or when the dose is increased. Dizziness, light-headedness or fainting may occur, especially when rising from a lying or sitting position. Getting up slowly may help lessen the problem. These effects may also occur if you drink alcohol, stand for long periods of time, exercise, or if the weather is hot. While taking prazosin HCl, be careful in the amount of alcohol you drink. Also, use extra care during exercise or hot weather, or if standing for long periods. Check with your physician if you have any questions.

Prazosin HCl Organisms Affected

Humans and other mammals