Minipress Xl
Brand names,
Minipress Xl
Analogs
Minipress Xl
Brand Names Mixture
Minipress Xl
Chemical_Formula
C19H21N5O4
Minipress Xl
RX_link
http://www.rxlist.com/cgi/generic3/prazosin.htm
Minipress Xl
fda sheet
Minipress Xl
msds (material safety sheet)
Minipress Xl
Synthesis Reference
No information avaliable
Minipress Xl
Molecular Weight
383.401 g/mol
Minipress Xl
Melting Point
279 oC
Minipress Xl
H2O Solubility
0.2 mg/mL (as HCl salt)
Minipress Xl
State
Solid
Minipress Xl
LogP
0.934
Minipress Xl
Dosage Forms
Tablet
Minipress Xl
Indication
For treatment of hypertension and chronic heart failure.
Minipress Xl
Pharmacology
Prazosin is an alpha-adrenergic blocking agent used to treat hypertension and benign prostatic hyperplasia. Accordingly, Prazosin is a selective inhibitor of the alpha1 subtype of alpha adrenergic receptors. In the human prostate, Prazosin antagonizes phenylephrine (alpha1 agonist)-induced contractions, in vitro, and binds with high affinity to the alpha1c adrenoceptor, which is thought to be the predominant functional type in the prostate. Studies in normal human subjects have shown that Prazosin competitively antagonized the pressor effects of phenylephrine (an alpha1 agonist) and the systolic pressor effect of norepinephrine. The antihypertensive effect of Prazosin results from a decrease in systemic vascular resistance and the parent compound Prazosin is primarily responsible for the antihypertensive activity.
Minipress Xl
Absorption
Well-absorbed from gastrointestinal tract; bioavailability is variable (50 to 85%).
Minipress Xl
side effects and Toxicity
No information avaliable
Minipress Xl
Patient Information
Dizziness or drowsiness may occur after the first dose of this medicine. Avoid driving or performing hazardous
tasks for the first 24 hours after taking this medicine or when the dose is increased. Dizziness, light-headedness or
fainting may occur, especially when rising from a lying or sitting position. Getting up slowly may help lessen the
problem. These effects may also occur if you drink alcohol, stand for long periods of time, exercise, or if the
weather is hot. While taking prazosin HCl, be careful in the amount of alcohol you drink. Also, use extra care during
exercise or hot weather, or if standing for long periods. Check with your physician if you have any questions.
Minipress Xl
Organisms Affected
Humans and other mammals