Etretinate
Etretinate Brand names, Etretinate Analogs
Etretinate Brand Names Mixture
- No information avaliable
Etretinate Chemical_Formula
C23H30O3
Etretinate RX_link
No information avaliable
Etretinate fda sheet
Etretinate msds (material safety sheet)
Etretinate Synthesis Reference
No information avaliable
Etretinate Molecular Weight
354.483 g/mol
Etretinate Melting Point
No information avaliable
Etretinate H2O Solubility
No information avaliable
Etretinate State
Solid
Etretinate LogP
5.59
Etretinate Dosage Forms
Tablet
Etretinate Indication
For the treatment of severe psoriasis in adults.
Etretinate Pharmacology
The active metabolite responsible for etretinate's effects, acitretin, is a retinoid. Retinoids have a structure similar to vitamin A and are involved in the normal growth of skin cells. Acitretin works by inhibiting the excessive cell growth and keratinisation (process by which skin cells become thickened due to the deposition of a protein within them) seen in psoriasis. It therefore reduces the thickening of the skin, plaque formation and scaling.
Etretinate Absorption
Absorbed in the small intestine. Studies in normal volunteers indicate that the absorption of etretinate is greater in patients consuming whole milk or a high-fat diet than in patients in a fasting state.
Etretinate side effects and Toxicity
Symptoms of overdose include headache and vertigo.
Etretinate Patient Information
Etretinate Organisms Affected
Humans and other mammals
