Etodolac
Brand names,
Etodolac
Analogs
Etodolac
Brand Names Mixture
Etodolac
Chemical_Formula
C17H21NO3
Etodolac
RX_link
http://www.rxlist.com/cgi/generic/etodolac.htm
Etodolac
fda sheet
Etodolac
msds (material safety sheet)
Etodolac
Synthesis Reference
C. A. Demerson et al., U.S. Pat. 3,939,178 (1976)
Etodolac
Molecular Weight
287.354 g/mol
Etodolac
Melting Point
145-148 oC
Etodolac
H2O Solubility
16 mg/L
Etodolac
State
Solid
Etodolac
LogP
No information avaliable
Etodolac
Dosage Forms
Tablet; Tablet (extended-release)
Etodolac
Indication
For acute and long-term use in the management of signs and symptoms of osteoarthritis and rheumatoid arthritis, as well as for the management of pain.
Etodolac
Pharmacology
Etodolac, an antiinflammatory agent with analgesic and antipyretic properties, is used to treat osteoarthritis and control acute pain.
Etodolac
Absorption
Based on mass balance studies, the systemic availability of etodolac from either the tablet or capsule formulation, is at least 80%.
Etodolac
side effects and Toxicity
Symptoms of overdose include lethargy, drowsiness, nausea, vomiting, and epigastric pain.
Etodolac
Patient Information
Lodine, like other drugs of its class, can cause discomfort and, rarely, more serious side effects, such as
gastrointestinal bleeding, which may result in hospitalization and even fatal outcomes. Although serious GI tract
ulcerations and bleeding can occur without warning symptoms, patients should be alert for the signs and symptoms of
ulcerations and bleeding, and should ask for medical advice when observing any indicative sign or symptom. Patients
should be informed of the importance of this follow-up Effects Risk of GI Ulceration, Bleeding, and
Perforation).
Patients on Lodine (etodolac capsules and tablets) should report to their physicians signs or symptoms of
gastrointestinal ulceration or bleeding, blurred vision or other eye symptoms, skin rash, weight gain, or edema.
Patients should also be instructed to seek medical emergency help in case of an occurrence of anaphylactoid
reactions.
Etodolac
Organisms Affected
Humans and other mammals