Etodolic Acid
Brand names,
Etodolic Acid
Analogs
Etodolic Acid
Brand Names Mixture
Etodolic Acid
Chemical_Formula
C17H21NO3
Etodolic Acid
RX_link
http://www.rxlist.com/cgi/generic/etodolac.htm
Etodolic Acid
fda sheet
Etodolic Acid
msds (material safety sheet)
Etodolic Acid
Synthesis Reference
C. A. Demerson et al., U.S. Pat. 3,939,178 (1976)
Etodolic Acid
Molecular Weight
287.354 g/mol
Etodolic Acid
Melting Point
145-148 oC
Etodolic Acid
H2O Solubility
16 mg/L
Etodolic Acid
State
Solid
Etodolic Acid
LogP
No information avaliable
Etodolic Acid
Dosage Forms
Tablet; Tablet (extended-release)
Etodolic Acid
Indication
For acute and long-term use in the management of signs and symptoms of osteoarthritis and rheumatoid arthritis, as well as for the management of pain.
Etodolic Acid
Pharmacology
Etodolac, an antiinflammatory agent with analgesic and antipyretic properties, is used to treat osteoarthritis and control acute pain.
Etodolic Acid
Absorption
Based on mass balance studies, the systemic availability of etodolac from either the tablet or capsule formulation, is at least 80%.
Etodolic Acid
side effects and Toxicity
Symptoms of overdose include lethargy, drowsiness, nausea, vomiting, and epigastric pain.
Etodolic Acid
Patient Information
Lodine, like other drugs of its class, can cause discomfort and, rarely, more serious side effects, such as
gastrointestinal bleeding, which may result in hospitalization and even fatal outcomes. Although serious GI tract
ulcerations and bleeding can occur without warning symptoms, patients should be alert for the signs and symptoms of
ulcerations and bleeding, and should ask for medical advice when observing any indicative sign or symptom. Patients
should be informed of the importance of this follow-up Effects Risk of GI Ulceration, Bleeding, and
Perforation).
Patients on Lodine (etodolac capsules and tablets) should report to their physicians signs or symptoms of
gastrointestinal ulceration or bleeding, blurred vision or other eye symptoms, skin rash, weight gain, or edema.
Patients should also be instructed to seek medical emergency help in case of an occurrence of anaphylactoid
reactions.
Etodolic Acid
Organisms Affected
Humans and other mammals