PharmacyCodes



Duloxetine Hcl en es it fr

Duloxetine Hcl Brand names, Duloxetine Hcl Analogs

Duloxetine Hcl Brand Names Mixture

  • No information avaliable

Duloxetine Hcl Chemical_Formula

C18H19NOS

Duloxetine Hcl RX_link

http://www.rxlist.com/cgi/generic/cymbalta.htm

Duloxetine Hcl fda sheet

Duloxetine_Hcl FDA

Duloxetine Hcl msds (material safety sheet)

Duloxetine_Hcl MSDS

Duloxetine Hcl Synthesis Reference

No information avaliable

Duloxetine Hcl Molecular Weight

297.416 g/mol

Duloxetine Hcl Melting Point

No information avaliable

Duloxetine Hcl H2O Solubility

Slightly soluble

Duloxetine Hcl State

Solid

Duloxetine Hcl LogP

5.024

Duloxetine Hcl Dosage Forms

Capsule

Duloxetine Hcl Indication

For the treatment of major depressive disorder (MDD).

Duloxetine Hcl Pharmacology

Duloxetine is in a class of medications called selective serotonin and norepinephrine reuptake inhibitors (SSNRIs) and primarily targets major depressive disorders (MDD) and stress urinary incontinence (SUI). Duloxetine is also used to treat pain and tingling caused by diabetic neuropathy (damage to nerves that can develop in people who have diabetes). Known also as LY248686, it is a potent dual inhibitor of serotonin (5-hydroxytryptamine, 5-HT) and norepinephrine (NE) reuptake, possessing comparable affinities in binding to NE and 5-HT transport sites. Interestingly, its behavior contrasts to most other dual-reuptake inhibitors. Furthermore, duloxentine lacks affinity for monoamine receptors within the central nervous system.

Duloxetine Hcl Absorption

Orally administered duloxetine hydrochloride is well absorbed.

Duloxetine Hcl side effects and Toxicity

Oral, rat LD50: 491 mg/kg for males and 279 mg/kg for females. Symptoms of overdose include tremors, convulsions, reduced activity, slow pupillary response, intermittent tremors, and rigidity.

Duloxetine Hcl Patient Information

No information avaliable

Duloxetine Hcl Organisms Affected

Humans and other mammals