Duloxetine HCl
Duloxetine HCl Brand names, Duloxetine HCl Analogs
Duloxetine HCl Brand Names Mixture
- No information avaliable
Duloxetine HCl Chemical_Formula
C18H19NOS
Duloxetine HCl RX_link
http://www.rxlist.com/cgi/generic/cymbalta.htm
Duloxetine HCl fda sheet
Duloxetine HCl msds (material safety sheet)
Duloxetine HCl Synthesis Reference
No information avaliable
Duloxetine HCl Molecular Weight
297.416 g/mol
Duloxetine HCl Melting Point
No information avaliable
Duloxetine HCl H2O Solubility
Slightly soluble
Duloxetine HCl State
Solid
Duloxetine HCl LogP
5.024
Duloxetine HCl Dosage Forms
Capsule
Duloxetine HCl Indication
For the treatment of major depressive disorder (MDD).
Duloxetine HCl Pharmacology
Duloxetine is in a class of medications called selective serotonin and norepinephrine reuptake inhibitors (SSNRIs) and primarily targets major depressive disorders (MDD) and stress urinary incontinence (SUI). Duloxetine is also used to treat pain and tingling caused by diabetic neuropathy (damage to nerves that can develop in people who have diabetes). Known also as LY248686, it is a potent dual inhibitor of serotonin (5-hydroxytryptamine, 5-HT) and norepinephrine (NE) reuptake, possessing comparable affinities in binding to NE and 5-HT transport sites. Interestingly, its behavior contrasts to most other dual-reuptake inhibitors. Furthermore, duloxentine lacks affinity for monoamine receptors within the central nervous system.
Duloxetine HCl Absorption
Orally administered duloxetine hydrochloride is well absorbed.
Duloxetine HCl side effects and Toxicity
Oral, rat LD50: 491 mg/kg for males and 279 mg/kg for females. Symptoms of overdose include tremors, convulsions, reduced activity, slow pupillary response, intermittent tremors, and rigidity.
Duloxetine HCl Patient Information
No information avaliable
Duloxetine HCl Organisms Affected
Humans and other mammals
