Duloxetine

• Antidepressants
• ATC:N06AB

• Cymbalta
• Domperidone
• Duloxetine HCl
• Duloxetine Hydrochloride
• Yentreve

• No information avaliable

C₁₈H₁₉NOS

http://www.rxlist.com/cgi/generic/cymbalta.htm

Duloxetine FDA

Duloxetine MSDS

No information avaliable

297.416 g/mol

No information avaliable

Slightly soluble

Solid

5.024

Capsule

For the treatment of major depressive disorder (MDD).

Duloxetine is in a class of medications called selective serotonin and norepinephrine reuptake inhibitors (SSNRIs) and primarily targets major depressive disorders (MDD) and stress urinary incontinence (SUI). Duloxetine is also used to treat pain and tingling caused by diabetic neuropathy (damage to nerves that can develop in people who have diabetes). Known also as LY248686, it is a potent dual inhibitor of serotonin (5-hydroxytryptamine, 5-HT) and norepinephrine (NE) reuptake, possessing comparable affinities in binding to NE and 5-HT transport sites. Interestingly, its behavior contrasts to most other dual-reuptake inhibitors. Furthermore, duloxentine lacks affinity for monoamine receptors within the central nervous system.

Orally administered duloxetine hydrochloride is well absorbed.

Oral, rat LD₅₀: 491 mg/kg for males and 279 mg/kg for females. Symptoms of overdose include tremors, convulsions, reduced activity, slow pupillary response, intermittent tremors, and rigidity.

No information avaliable

Humans and other mammals