Dolasetron
Brand names,
Dolasetron
Analogs
Dolasetron
Brand Names Mixture
Dolasetron
Chemical_Formula
C19H20N2O3
Dolasetron
RX_link
http://www.rxlist.com/cgi/generic2/dolaset.htm
Dolasetron
fda sheet
Dolasetron
msds (material safety sheet)
Dolasetron
Synthesis Reference
M. W. Gittos, Eur. pat. Appl. 266,730 (1988 to Merrell Dow).
Dolasetron
Molecular Weight
324.374 g/mol
Dolasetron
Melting Point
278 oC
Dolasetron
H2O Solubility
Freely soluble in water
Dolasetron
State
Solid
Dolasetron
LogP
2.347
Dolasetron
Dosage Forms
Intravenous injection; Tablet
Dolasetron
Indication
For the prevention of nausea and vomiting associated with moderately-emetogenic cancer chemotherapy, including initial and repeat courses and prevention of postoperative nausea and vomiting
Dolasetron
Pharmacology
Dolasetron is an antinauseant and antiemetic agent indicated for the prevention of nausea and vomiting associated with moderately-emetogenic cancer chemotherapy and for the prevention of postoperative nausea and vomiting. Dolasetron is a highly specific and selective serotonin 5-HT3 receptor antagonist, not shown to have activity at other known serotonin receptors and with low affinity for dopamine receptors.
Dolasetron
Absorption
Orally-administered dolasetron is well absorbed
Dolasetron
side effects and Toxicity
No information avaliable
Dolasetron
Patient Information
Dolasetron
Organisms Affected
Humans and other mammals