Anzemet
Brand names,
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Analogs
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Brand Names Mixture
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Chemical_Formula
C19H20N2O3
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RX_link
http://www.rxlist.com/cgi/generic2/dolaset.htm
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fda sheet
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msds (material safety sheet)
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Synthesis Reference
M. W. Gittos, Eur. pat. Appl. 266,730 (1988 to Merrell Dow).
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Molecular Weight
324.374 g/mol
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Melting Point
278 oC
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H2O Solubility
Freely soluble in water
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State
Solid
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LogP
2.347
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Dosage Forms
Intravenous injection; Tablet
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Indication
For the prevention of nausea and vomiting associated with moderately-emetogenic cancer chemotherapy, including initial and repeat courses and prevention of postoperative nausea and vomiting
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Pharmacology
Dolasetron is an antinauseant and antiemetic agent indicated for the prevention of nausea and vomiting associated with moderately-emetogenic cancer chemotherapy and for the prevention of postoperative nausea and vomiting. Dolasetron is a highly specific and selective serotonin 5-HT3 receptor antagonist, not shown to have activity at other known serotonin receptors and with low affinity for dopamine receptors.
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Absorption
Orally-administered dolasetron is well absorbed
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side effects and Toxicity
No information avaliable
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Patient Information
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Organisms Affected
Humans and other mammals