Dolasteron
Brand names,
Dolasteron
Analogs
Dolasteron
Brand Names Mixture
Dolasteron
Chemical_Formula
C19H20N2O3
Dolasteron
RX_link
http://www.rxlist.com/cgi/generic2/dolaset.htm
Dolasteron
fda sheet
Dolasteron
msds (material safety sheet)
Dolasteron
Synthesis Reference
M. W. Gittos, Eur. pat. Appl. 266,730 (1988 to Merrell Dow).
Dolasteron
Molecular Weight
324.374 g/mol
Dolasteron
Melting Point
278 oC
Dolasteron
H2O Solubility
Freely soluble in water
Dolasteron
State
Solid
Dolasteron
LogP
2.347
Dolasteron
Dosage Forms
Intravenous injection; Tablet
Dolasteron
Indication
For the prevention of nausea and vomiting associated with moderately-emetogenic cancer chemotherapy, including initial and repeat courses and prevention of postoperative nausea and vomiting
Dolasteron
Pharmacology
Dolasetron is an antinauseant and antiemetic agent indicated for the prevention of nausea and vomiting associated with moderately-emetogenic cancer chemotherapy and for the prevention of postoperative nausea and vomiting. Dolasetron is a highly specific and selective serotonin 5-HT3 receptor antagonist, not shown to have activity at other known serotonin receptors and with low affinity for dopamine receptors.
Dolasteron
Absorption
Orally-administered dolasetron is well absorbed
Dolasteron
side effects and Toxicity
No information avaliable
Dolasteron
Patient Information
Dolasteron
Organisms Affected
Humans and other mammals