Docetaxel

Docetaxel Brand names, Docetaxel Analogs

Docetaxel Brand Names Mixture

No information avaliable

Docetaxel Chemical_Formula

C₄₃H₅₃NO₁₄

Docetaxel RX_link

http://www.rxlist.com/cgi/generic3/docetaxel.htm

Docetaxel fda sheet

Docetaxel FDA

Docetaxel msds (material safety sheet)

Docetaxel MSDS

Docetaxel Synthesis Reference

No information avaliable

Docetaxel Molecular Weight

807.879 g/mol

Docetaxel Melting Point

232 ^oC

Docetaxel H₂O Solubility

Practically insoluble (0.025 mg/L)

Docetaxel State

Solid

Docetaxel LogP

4.258

Docetaxel Dosage Forms

Solution: single-dose vials containing 20 mg (0.5 mL) or 80 mg (2 mL) docetaxel (anhydrous).

Docetaxel Indication

For the treatment of patients with locally advanced or metastatic breast cancer after failure of prior chemotherapy. Also used as a single agent in the treatment of patients with locally advanced or metastatic non-small cell lung cancer after failure of prior platinum-based chemotherapy. Lastly, for use, in combination with prednisone, in the treatment of patients with androgen independent (hormone refractory) metastatic prostate cancer.

Docetaxel Pharmacology

Docetaxel is a taxoid antineoplastic agent. It promotes the assembly of microtubules from tubulin dimers and stabilizes microtubules by preventing depolymerization. This stability results in the inhibition of the normal dynamic reorganization of the microtubule network that is essential for vital interphase and mitotic cellular functions. In addition, docetaxel induces abnormal arrays or "bundles" of microtubules throughout the cell cycle and multiple asters of microtubules during mitosis.

Docetaxel Absorption