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TXL Brand names, TXL Analogs

TXL Brand Names Mixture

  • No information avaliable

TXL Chemical_Formula


TXL RX_link


TXL fda sheet


TXL msds (material safety sheet)


TXL Synthesis Reference

No information avaliable

TXL Molecular Weight

807.879 g/mol

TXL Melting Point

232 oC

TXL H2O Solubility

Practically insoluble (0.025 mg/L)

TXL State




TXL Dosage Forms

Solution: single-dose vials containing 20 mg (0.5 mL) or 80 mg (2 mL) docetaxel (anhydrous).

TXL Indication

For the treatment of patients with locally advanced or metastatic breast cancer after failure of prior chemotherapy. Also used as a single agent in the treatment of patients with locally advanced or metastatic non-small cell lung cancer after failure of prior platinum-based chemotherapy. Lastly, for use, in combination with prednisone, in the treatment of patients with androgen independent (hormone refractory) metastatic prostate cancer.

TXL Pharmacology

Docetaxel is a taxoid antineoplastic agent. It promotes the assembly of microtubules from tubulin dimers and stabilizes microtubules by preventing depolymerization. This stability results in the inhibition of the normal dynamic reorganization of the microtubule network that is essential for vital interphase and mitotic cellular functions. In addition, docetaxel induces abnormal arrays or "bundles" of microtubules throughout the cell cycle and multiple asters of microtubules during mitosis.

TXL Absorption

No information avaliable

TXL side effects and Toxicity

Oral LD50 in rat is >2000 mg/kg. Anticipated complications of overdosage include: bone marrow suppression, peripheral neurotoxicity, and mucositis. In two reports of overdose, one patient received 150 mg/m2 and the other received 200 mg/m2 as 1-hour infusions. Both patients experienced severe neutropenia, mild asthenia, cutaneous reactions, and mild paresthesia, and recovered without incident.

TXL Patient Information

TXL Organisms Affected

Humans and other mammals