TXL

TXL Brand names, TXL Analogs

TXL Brand Names Mixture

No information avaliable

TXL Chemical_Formula

C₄₃H₅₃NO₁₄

TXL RX_link

http://www.rxlist.com/cgi/generic3/docetaxel.htm

TXL fda sheet

TXL FDA

TXL msds (material safety sheet)

TXL MSDS

TXL Synthesis Reference

No information avaliable

TXL Molecular Weight

807.879 g/mol

TXL Melting Point

232 ^oC

TXL H₂O Solubility

Practically insoluble (0.025 mg/L)

TXL State

Solid

TXL LogP

4.258

TXL Dosage Forms

Solution: single-dose vials containing 20 mg (0.5 mL) or 80 mg (2 mL) docetaxel (anhydrous).

TXL Indication

For the treatment of patients with locally advanced or metastatic breast cancer after failure of prior chemotherapy. Also used as a single agent in the treatment of patients with locally advanced or metastatic non-small cell lung cancer after failure of prior platinum-based chemotherapy. Lastly, for use, in combination with prednisone, in the treatment of patients with androgen independent (hormone refractory) metastatic prostate cancer.

TXL Pharmacology

Docetaxel is a taxoid antineoplastic agent. It promotes the assembly of microtubules from tubulin dimers and stabilizes microtubules by preventing depolymerization. This stability results in the inhibition of the normal dynamic reorganization of the microtubule network that is essential for vital interphase and mitotic cellular functions. In addition, docetaxel induces abnormal arrays or "bundles" of microtubules throughout the cell cycle and multiple asters of microtubules during mitosis.

TXL Absorption