Docetaxel, Trihydrate

Docetaxel, Trihydrate Brand names, Docetaxel, Trihydrate Analogs

Docetaxel, Trihydrate Brand Names Mixture

No information avaliable

Docetaxel, Trihydrate Chemical_Formula

C₄₃H₅₃NO₁₄

Docetaxel, Trihydrate RX_link

http://www.rxlist.com/cgi/generic3/docetaxel.htm

Docetaxel, Trihydrate fda sheet

Docetaxel,_Trihydrate FDA

Docetaxel, Trihydrate msds (material safety sheet)

Docetaxel,_Trihydrate MSDS

Docetaxel, Trihydrate Synthesis Reference

No information avaliable

Docetaxel, Trihydrate Molecular Weight

807.879 g/mol

Docetaxel, Trihydrate Melting Point

232 ^oC

Docetaxel, Trihydrate H₂O Solubility

Practically insoluble (0.025 mg/L)

Docetaxel, Trihydrate State

Solid

Docetaxel, Trihydrate LogP

4.258

Docetaxel, Trihydrate Dosage Forms

Solution: single-dose vials containing 20 mg (0.5 mL) or 80 mg (2 mL) docetaxel (anhydrous).

Docetaxel, Trihydrate Indication

For the treatment of patients with locally advanced or metastatic breast cancer after failure of prior chemotherapy. Also used as a single agent in the treatment of patients with locally advanced or metastatic non-small cell lung cancer after failure of prior platinum-based chemotherapy. Lastly, for use, in combination with prednisone, in the treatment of patients with androgen independent (hormone refractory) metastatic prostate cancer.

Docetaxel, Trihydrate Pharmacology

Docetaxel is a taxoid antineoplastic agent. It promotes the assembly of microtubules from tubulin dimers and stabilizes microtubules by preventing depolymerization. This stability results in the inhibition of the normal dynamic reorganization of the microtubule network that is essential for vital interphase and mitotic cellular functions. In addition, docetaxel induces abnormal arrays or "bundles" of microtubules throughout the cell cycle and multiple asters of microtubules during mitosis.

Docetaxel, Trihydrate Absorption