Taxotere

Taxotere Brand names, Taxotere Analogs

Taxotere Brand Names Mixture

No information avaliable

Taxotere Chemical_Formula

C₄₃H₅₃NO₁₄

Taxotere RX_link

http://www.rxlist.com/cgi/generic3/docetaxel.htm

Taxotere fda sheet

Taxotere FDA

Taxotere msds (material safety sheet)

Taxotere MSDS

Taxotere Synthesis Reference

No information avaliable

Taxotere Molecular Weight

807.879 g/mol

Taxotere Melting Point

232 ^oC

Taxotere H₂O Solubility

Practically insoluble (0.025 mg/L)

Taxotere State

Solid

Taxotere LogP

4.258

Taxotere Dosage Forms

Solution: single-dose vials containing 20 mg (0.5 mL) or 80 mg (2 mL) docetaxel (anhydrous).

Taxotere Indication

For the treatment of patients with locally advanced or metastatic breast cancer after failure of prior chemotherapy. Also used as a single agent in the treatment of patients with locally advanced or metastatic non-small cell lung cancer after failure of prior platinum-based chemotherapy. Lastly, for use, in combination with prednisone, in the treatment of patients with androgen independent (hormone refractory) metastatic prostate cancer.

Taxotere Pharmacology

Docetaxel is a taxoid antineoplastic agent. It promotes the assembly of microtubules from tubulin dimers and stabilizes microtubules by preventing depolymerization. This stability results in the inhibition of the normal dynamic reorganization of the microtubule network that is essential for vital interphase and mitotic cellular functions. In addition, docetaxel induces abnormal arrays or "bundles" of microtubules throughout the cell cycle and multiple asters of microtubules during mitosis.

Taxotere Absorption