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Brand names,
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Analogs
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Brand Names Mixture
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Chemical_Formula
C18H14Cl4N2O
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RX_link
http://www.rxlist.com/cgi/generic2/micon.htm
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fda sheet
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msds (material safety sheet)
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Synthesis Reference
No information avaliable
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Molecular Weight
416.127 g/mol
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Melting Point
159 - 163 oC
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H2O Solubility
1g/100mL (20°C)
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State
Solid
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LogP
6.02
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Dosage Forms
Topical cream (2%); Vaginal cream (2%); Vaginal suppositories (100mg, 200mg)
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Indication
For topical application in the treatment of tinea pedis (athlete’s foot), tinea cruris, and tinea corporis caused by Trichophyton rubrum, Trichophyton mentagrophytes, and Epidermophyton floccosum, in the treatment of cutaneous candidiasis (moniliasis), and in the treatment of tinea versicolor.
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Pharmacology
Miconazole is an anti-fungal medication related to fluconazole (Diflucan), ketoconazole (Nizoral), itraconazole (Sporanox), and clotrimazole (Lotrimin, Mycelex). It is used either on the skin or in the vagina for fungal infections. Miconazole was approved by the FDA in 1974. Miconazole prevents fungal organisms from producing vital substances required for growth and function. This medication is effective only for infections caused by fungal organisms. It will not work for bacterial or viral infections.
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Absorption
No information avaliable
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side effects and Toxicity
Oral, mouse: LD50 = 3800 mg/kg; Oral, rat: LD50 = 3 gm/kg. Ingestion of the amounts of the components contained in a tube of cream are unlikely to produce overdosage and toxic effects.
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Patient Information
No information avaliable
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Organisms Affected
Fungi, yeast and protozoans