Dea No. 1680
Brand names,
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Analogs
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Brand Names Mixture
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Chemical_Formula
C15H15NO2S
Dea No. 1680
RX_link
http://www.rxlist.com/cgi/generic2/modafinil.htm
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fda sheet
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msds (material safety sheet)
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Synthesis Reference
L. Lafon, U.S. pat. 4,927,855, (1990)
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Molecular Weight
273.351 g/mol
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Melting Point
164-166 oC
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H2O Solubility
Slightly soluble
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State
Solid
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LogP
1.736
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Dosage Forms
Tablet
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Indication
To improve wakefulness in patients with excessive daytime sleepiness (EDS) associated with narcolepsy.
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Pharmacology
Modafinil is a stimulant drug marketed as a 'wakefulness promoting agent' and is one of the stimulants used in the treatment of narcolepsy. Narcolepsy is caused by dysfunction of a family of wakefulness-promoting and sleep-suppressing peptides, the orexins, whose neurons are activated by modafinil. The prexin neuron activation is associated with psychoactivation and euphoria. Modafinil is not indicated for complaints of lack of energy or fatigue; but it appears to be very helpful for some patients. Also, it has been used in the treatment of hypersomnia, a disorder in which patients lack the capacity for meaningful sleep and may require ten or more hours per day. Recent studies have have found that modafinil may help recovering cocaine addicts fight their addiction.
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Absorption
Rapid following oral administration.
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side effects and Toxicity
No information avaliable
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Patient Information
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Organisms Affected
Humans and other mammals