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Dtic-Dome Brand names, Dtic-Dome Analogs

Dtic-Dome Brand Names Mixture

  • No information avaliable

Dtic-Dome Chemical_Formula


Dtic-Dome RX_link


Dtic-Dome fda sheet


Dtic-Dome msds (material safety sheet)

Dtic-Dome Synthesis Reference

Zambito et al.; Nucleic Acid Chem.; 1978; 3,8,9,10(1978);.

Dtic-Dome Molecular Weight

182.183 g/mol

Dtic-Dome Melting Point

205 oC

Dtic-Dome H2O Solubility

4220 mg/L

Dtic-Dome State


Dtic-Dome LogP


Dtic-Dome Dosage Forms

Liquid; Powder for solution

Dtic-Dome Indication

For the treatment of metastatic malignant melanoma. In addition, DTIC-Dome is also indicated for Hodgkin's disease as a secondary-line therapy when used in combination with other effective agents

Dtic-Dome Pharmacology

After intravenous administration of DTIC-Dome, the volume of distribution exceeds total body water content suggesting localization in some body tissue, probably the liver. Its disappearance from the plasma is biphasic with initial half-life of 19 minutes and a terminal half-life of 5 hours. 1 In a patient with renal and hepatic dysfunctions, the half-lives were lengthened to 55 minutes and 7.2 hours. 1 The average cumulative excretion of unchanged DTIC in the urine is 40% of the injected dose in 6 hours. 1 DTIC is subject to renal tubular secretion rather than glomerular filtration. At therapeutic concentrations DTIC is not appreciably bound to human plasma protein.

Dtic-Dome Absorption

Erratic, slow and incomplete

Dtic-Dome side effects and Toxicity

LD50=350mg/kg (orally in mice)

Dtic-Dome Patient Information

This medicine is a type of chemotherapy for treating cancers of the
blood and certain other cancers. This medicine interfers with the way
cancer cells grow, Take your doses on a regular scheduled time and DO
NOT take this medicine more often than directed by your health care
provider. Finish the full course prescribed by your health care provider.
DO NOT stop taking this medicine unless diredted to do so by your health
care provider. While taking this medicine, you make get infection more
easily. Call your doctor if you get a fever, chills, or sore throat.
Drink plenty of water with this medicine.

Dtic-Dome Organisms Affected

Humans and other mammals