DTIE
DTIE Brand names, DTIE Analogs
DTIE Brand Names Mixture
- No information avaliable
DTIE Chemical_Formula
C6H10N6O
DTIE RX_link
http://www.rxlist.com/cgi/generic2/dacarbazine.htm
DTIE fda sheet
DTIE msds (material safety sheet)
DTIE Synthesis Reference
Zambito et al.; Nucleic Acid Chem.; 1978; 3,8,9,10(1978);.
DTIE Molecular Weight
182.183 g/mol
DTIE Melting Point
205 oC
DTIE H2O Solubility
4220 mg/L
DTIE State
Solid
DTIE LogP
-1.938
DTIE Dosage Forms
Liquid; Powder for solution
DTIE Indication
For the treatment of metastatic malignant melanoma. In addition, DTIC-Dome is also indicated for Hodgkin's disease as a secondary-line therapy when used in combination with other effective agents
DTIE Pharmacology
After intravenous administration of DTIC-Dome, the volume of distribution exceeds total body water content suggesting localization in some body tissue, probably the liver. Its disappearance from the plasma is biphasic with initial half-life of 19 minutes and a terminal half-life of 5 hours. 1 In a patient with renal and hepatic dysfunctions, the half-lives were lengthened to 55 minutes and 7.2 hours. 1 The average cumulative excretion of unchanged DTIC in the urine is 40% of the injected dose in 6 hours. 1 DTIC is subject to renal tubular secretion rather than glomerular filtration. At therapeutic concentrations DTIC is not appreciably bound to human plasma protein.
DTIE Absorption
Erratic, slow and incomplete
DTIE side effects and Toxicity
LD50=350mg/kg (orally in mice)
DTIE Patient Information
This medicine is a type of chemotherapy for treating cancers of the
blood and certain other cancers. This medicine interfers with the way
cancer cells grow, Take your doses on a regular scheduled time and DO
NOT take this medicine more often than directed by your health care
provider. Finish the full course prescribed by your health care provider.
DO NOT stop taking this medicine unless diredted to do so by your health
care provider. While taking this medicine, you make get infection more
easily. Call your doctor if you get a fever, chills, or sore throat.
Drink plenty of water with this medicine.
blood and certain other cancers. This medicine interfers with the way
cancer cells grow, Take your doses on a regular scheduled time and DO
NOT take this medicine more often than directed by your health care
provider. Finish the full course prescribed by your health care provider.
DO NOT stop taking this medicine unless diredted to do so by your health
care provider. While taking this medicine, you make get infection more
easily. Call your doctor if you get a fever, chills, or sore throat.
Drink plenty of water with this medicine.
DTIE Organisms Affected
Humans and other mammals
