DMSA
DMSA Brand names, DMSA Analogs
DMSA Brand Names Mixture
- Didrocal (Calcium Carbonate + Etidronate Disodium)
DMSA Chemical_Formula
C9H14N5O4P
DMSA RX_link
http://www.rxlist.com/cgi/generic/viread.htm
DMSA fda sheet
DMSA msds (material safety sheet)
DMSA Synthesis Reference
No information avaliable
DMSA Molecular Weight
287.213 g/mol
DMSA Melting Point
276-280oC
DMSA H2O Solubility
13.4 mg/mL in distilled water at 25°C (disoproxil fumarate salt)
DMSA State
Solid
DMSA LogP
0.01
DMSA Dosage Forms
Tablets for oral administration (300 mg)
DMSA Indication
For use, in combination with other antiretroviral agents, for the treatment of HIV-1 infection.
DMSA Pharmacology
Tenofovir belongs to a class of antiretroviral drugs known as nucleotide analogue reverse transcriptase inhibitors (NtRTIs), which block reverse transcriptase, an enzyme crucial to viral production in HIV-infected people. Tenofovir is currently in late-stage clinical trials for the treatment of hepatitis B. Tenofovir disoproxil fumarate is an acyclic nucleoside phosphonate diester analog of adenosine monophosphate. Tenofovir requires initial diester hydrolysis for conversion to tenofovir and subsequent phosphorylations by cellular enzymes to form tenofovir diphosphate. Tenofovir diphosphate is a weak inhibitor of mammalian DNA polymerases α, β, and mitochondrial DNA polymerase γ.
DMSA Absorption
The oral bioavailability in fasted patients is approximately 25%. Administration of food (high fat meal containing 40 to 50% fat) increases the oral bioavailability, with an increase in the AUC of approximately 40%.
DMSA side effects and Toxicity
Limited clinical experience at doses higher than the therapeutic dose of tenofovir 300 mg is available. In Study 901 tenofovir disoproxil fumarate 600 mg was administered to 8 patients orally for 28 days. No severe adverse reactions were reported. The effects of higher doses are not known.
DMSA Patient Information
DMSA Organisms Affected
Human immunodeficiency virus
