Cyclobenzaprine
Cyclobenzaprine Brand names, Cyclobenzaprine Analogs
Cyclobenzaprine Brand Names Mixture
- No information avaliable
Cyclobenzaprine Chemical_Formula
C20H21N
Cyclobenzaprine RX_link
http://www.rxlist.com/cgi/generic/cyclobnz.htm
Cyclobenzaprine fda sheet
Cyclobenzaprine msds (material safety sheet)
Cyclobenzaprine Synthesis Reference
Villani et al.; J. Org. Med. Pharm. Chem. 5, 373 (1962)
Cyclobenzaprine Molecular Weight
275.387 g/mol
Cyclobenzaprine Melting Point
216-218 oC (HCl salt)
Cyclobenzaprine H2O Solubility
Freely Soluble
Cyclobenzaprine State
Solid
Cyclobenzaprine LogP
4.974
Cyclobenzaprine Dosage Forms
Tablet (5 mg, 10 mg)
Cyclobenzaprine Indication
For use as an adjunct to rest and physical therapy for relief of muscle spasm associated with acute, painful musculoskeletal conditions.
Cyclobenzaprine Pharmacology
Cyclobenzaprine, closely related to the antidepressant amitriptyline, is used as a skeletal muscle relaxant to reduce pain and tenderness and improve mobility. Unlike dantrolene, cyclobenzaprine cannot be used to treat muscle spasm secondary to cerebral or spinal cord disease.
Cyclobenzaprine Absorption
Slowly but well absorbed after oral administration
Cyclobenzaprine side effects and Toxicity
Oral mouse and rat LD50 are 338 mg/kg and 425 mg/kg respectively. Signs of overdose include agitation, coma, confusion, congestive heart failure, convulsions, dilated pupils, disturbed concentration, drowsiness, hallucinations, high or low temperature, increased heartbeats, irregular heart rhythms, muscle stiffness, overactive reflexes, severe low blood pressure, stupor, and vomiting.
Cyclobenzaprine Patient Information
FLEXERIL, especially when used with alcohol or other CNS depressants, may impair mental and/or physical abilities required for performance of hazardous tasks, such as operating machinery or driving a motor vehicle. In the elderly, the frequency and severity of adverse events associated with the use of cyclobenzaprine, with or without concomitant medications, is increased. In elderly patients, FLEXERIL should be initiated with a 5 mg dose and titrated slowly upward.
Cyclobenzaprine Organisms Affected
Humans and other mammals
