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Cyclobenzaprine Brand names, Cyclobenzaprine Analogs

Cyclobenzaprine Brand Names Mixture

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Cyclobenzaprine Chemical_Formula


Cyclobenzaprine RX_link

Cyclobenzaprine fda sheet

Cyclobenzaprine FDA

Cyclobenzaprine msds (material safety sheet)

Cyclobenzaprine Synthesis Reference

Villani et al.; J. Org. Med. Pharm. Chem. 5, 373 (1962)

Cyclobenzaprine Molecular Weight

275.387 g/mol

Cyclobenzaprine Melting Point

216-218 oC (HCl salt)

Cyclobenzaprine H2O Solubility

Freely Soluble

Cyclobenzaprine State


Cyclobenzaprine LogP


Cyclobenzaprine Dosage Forms

Tablet (5 mg, 10 mg)

Cyclobenzaprine Indication

For use as an adjunct to rest and physical therapy for relief of muscle spasm associated with acute, painful musculoskeletal conditions.

Cyclobenzaprine Pharmacology

Cyclobenzaprine, closely related to the antidepressant amitriptyline, is used as a skeletal muscle relaxant to reduce pain and tenderness and improve mobility. Unlike dantrolene, cyclobenzaprine cannot be used to treat muscle spasm secondary to cerebral or spinal cord disease.

Cyclobenzaprine Absorption

Slowly but well absorbed after oral administration

Cyclobenzaprine side effects and Toxicity

Oral mouse and rat LD50 are 338 mg/kg and 425 mg/kg respectively. Signs of overdose include agitation, coma, confusion, congestive heart failure, convulsions, dilated pupils, disturbed concentration, drowsiness, hallucinations, high or low temperature, increased heartbeats, irregular heart rhythms, muscle stiffness, overactive reflexes, severe low blood pressure, stupor, and vomiting.

Cyclobenzaprine Patient Information

FLEXERIL, especially when used with alcohol or other CNS depressants, may impair mental and/or physical abilities required for performance of hazardous tasks, such as operating machinery or driving a motor vehicle. In the elderly, the frequency and severity of adverse events associated with the use of cyclobenzaprine, with or without concomitant medications, is increased. In elderly patients, FLEXERIL should be initiated with a 5 mg dose and titrated slowly upward.

Cyclobenzaprine Organisms Affected

Humans and other mammals