Flexeril
Flexeril Brand names, Flexeril Analogs
Flexeril Brand Names Mixture
- No information avaliable
Flexeril Chemical_Formula
C20H21N
Flexeril RX_link
http://www.rxlist.com/cgi/generic/cyclobnz.htm
Flexeril fda sheet
Flexeril msds (material safety sheet)
Flexeril Synthesis Reference
Villani et al.; J. Org. Med. Pharm. Chem. 5, 373 (1962)
Flexeril Molecular Weight
275.387 g/mol
Flexeril Melting Point
216-218 oC (HCl salt)
Flexeril H2O Solubility
Freely Soluble
Flexeril State
Solid
Flexeril LogP
4.974
Flexeril Dosage Forms
Tablet (5 mg, 10 mg)
Flexeril Indication
For use as an adjunct to rest and physical therapy for relief of muscle spasm associated with acute, painful musculoskeletal conditions.
Flexeril Pharmacology
Cyclobenzaprine, closely related to the antidepressant amitriptyline, is used as a skeletal muscle relaxant to reduce pain and tenderness and improve mobility. Unlike dantrolene, cyclobenzaprine cannot be used to treat muscle spasm secondary to cerebral or spinal cord disease.
Flexeril Absorption
Slowly but well absorbed after oral administration
Flexeril side effects and Toxicity
Oral mouse and rat LD50 are 338 mg/kg and 425 mg/kg respectively. Signs of overdose include agitation, coma, confusion, congestive heart failure, convulsions, dilated pupils, disturbed concentration, drowsiness, hallucinations, high or low temperature, increased heartbeats, irregular heart rhythms, muscle stiffness, overactive reflexes, severe low blood pressure, stupor, and vomiting.
Flexeril Patient Information
FLEXERIL, especially when used with alcohol or other CNS depressants, may impair mental and/or physical abilities required for performance of hazardous tasks, such as operating machinery or driving a motor vehicle. In the elderly, the frequency and severity of adverse events associated with the use of cyclobenzaprine, with or without concomitant medications, is increased. In elderly patients, FLEXERIL should be initiated with a 5 mg dose and titrated slowly upward.
Flexeril Organisms Affected
Humans and other mammals
