Cyclobenzaprine HCL en es it fr

Cyclobenzaprine HCL Brand names, Cyclobenzaprine HCL Analogs

Cyclobenzaprine HCL Brand Names Mixture

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Cyclobenzaprine HCL Chemical_Formula


Cyclobenzaprine HCL RX_link

Cyclobenzaprine HCL fda sheet

Cyclobenzaprine_HCL FDA

Cyclobenzaprine HCL msds (material safety sheet)

Cyclobenzaprine HCL Synthesis Reference

Villani et al.; J. Org. Med. Pharm. Chem. 5, 373 (1962)

Cyclobenzaprine HCL Molecular Weight

275.387 g/mol

Cyclobenzaprine HCL Melting Point

216-218 oC (HCl salt)

Cyclobenzaprine HCL H2O Solubility

Freely Soluble

Cyclobenzaprine HCL State


Cyclobenzaprine HCL LogP


Cyclobenzaprine HCL Dosage Forms

Tablet (5 mg, 10 mg)

Cyclobenzaprine HCL Indication

For use as an adjunct to rest and physical therapy for relief of muscle spasm associated with acute, painful musculoskeletal conditions.

Cyclobenzaprine HCL Pharmacology

Cyclobenzaprine, closely related to the antidepressant amitriptyline, is used as a skeletal muscle relaxant to reduce pain and tenderness and improve mobility. Unlike dantrolene, cyclobenzaprine cannot be used to treat muscle spasm secondary to cerebral or spinal cord disease.

Cyclobenzaprine HCL Absorption

Slowly but well absorbed after oral administration

Cyclobenzaprine HCL side effects and Toxicity

Oral mouse and rat LD50 are 338 mg/kg and 425 mg/kg respectively. Signs of overdose include agitation, coma, confusion, congestive heart failure, convulsions, dilated pupils, disturbed concentration, drowsiness, hallucinations, high or low temperature, increased heartbeats, irregular heart rhythms, muscle stiffness, overactive reflexes, severe low blood pressure, stupor, and vomiting.

Cyclobenzaprine HCL Patient Information

FLEXERIL, especially when used with alcohol or other CNS depressants, may impair mental and/or physical abilities required for performance of hazardous tasks, such as operating machinery or driving a motor vehicle. In the elderly, the frequency and severity of adverse events associated with the use of cyclobenzaprine, with or without concomitant medications, is increased. In elderly patients, FLEXERIL should be initiated with a 5 mg dose and titrated slowly upward.

Cyclobenzaprine HCL Organisms Affected

Humans and other mammals