Cyclobenz

Cyclobenz Brand names, Cyclobenz Analogs

Cyclobenz Brand Names Mixture

No information avaliable

Cyclobenz Chemical_Formula

C₂₀H₂₁N

Cyclobenz RX_link

http://www.rxlist.com/cgi/generic/cyclobnz.htm

Cyclobenz fda sheet

Cyclobenz FDA

Cyclobenz msds (material safety sheet)

Cyclobenz Synthesis Reference

Villani et al.; J. Org. Med. Pharm. Chem. 5, 373 (1962)

Cyclobenz Molecular Weight

275.387 g/mol

Cyclobenz Melting Point

216-218 ^oC (HCl salt)

Cyclobenz H₂O Solubility

Freely Soluble

Cyclobenz State

Solid

Cyclobenz LogP

4.974

Cyclobenz Dosage Forms

Tablet (5 mg, 10 mg)

Cyclobenz Indication

For use as an adjunct to rest and physical therapy for relief of muscle spasm associated with acute, painful musculoskeletal conditions.

Cyclobenz Pharmacology

Cyclobenzaprine, closely related to the antidepressant amitriptyline, is used as a skeletal muscle relaxant to reduce pain and tenderness and improve mobility. Unlike dantrolene, cyclobenzaprine cannot be used to treat muscle spasm secondary to cerebral or spinal cord disease.

Cyclobenz Absorption

Slowly but well absorbed after oral administration

Cyclobenz side effects and Toxicity

Oral mouse and rat LD₅₀ are 338 mg/kg and 425 mg/kg respectively. Signs of overdose include agitation, coma, confusion, congestive heart failure, convulsions, dilated pupils, disturbed concentration, drowsiness, hallucinations, high or low temperature, increased heartbeats, irregular heart rhythms, muscle stiffness, overactive reflexes, severe low blood pressure, stupor, and vomiting.

Cyclobenz Patient Information

FLEXERIL, especially when used with alcohol or other CNS depressants, may impair mental and/or physical abilities required for performance of hazardous tasks, such as operating machinery or driving a motor vehicle. In the elderly, the frequency and severity of adverse events associated with the use of cyclobenzaprine, with or without concomitant medications, is increased. In elderly patients, FLEXERIL should be initiated with a 5 mg dose and titrated slowly upward.

Cyclobenz Organisms Affected

Humans and other mammals