Ciclopirox
Ciclopirox Brand names, Ciclopirox Analogs
Ciclopirox Brand Names Mixture
- No information avaliable
Ciclopirox Chemical_Formula
C12H17NO2
Ciclopirox RX_link
http://www.rxlist.com/cgi/generic3/penlac.htm
Ciclopirox fda sheet
Ciclopirox msds (material safety sheet)
Ciclopirox Synthesis Reference
No information avaliable
Ciclopirox Molecular Weight
207.269 g/mol
Ciclopirox Melting Point
144 oC
Ciclopirox H2O Solubility
No information avaliable
Ciclopirox State
Solid
Ciclopirox LogP
2.33
Ciclopirox Dosage Forms
Topical solution (8%)
Ciclopirox Indication
Used as a topical treatment in immunocompetent patients with mild to moderate onychomycosis of fingernails and toenails without lunula involvement, due to Trichophyton rubrum.
Ciclopirox Pharmacology
Ciclopirox is a broad-spectrum antifungal medication that also has antibacterial and anti-inflammatory properties. Its main mode of action is thought to be its high affinity for trivalent cations, which inhibit essential co-factors in enzymes. Ciclopirox exhibits either fungistatic or fungicidal activity in vitro against a broad spectrum of fungal organisms, such as dermatophytes, yeasts, dimorphic fungi, eumycetes, and actinomycetes. In addition to its broad spectrum of action, ciclopirox also exerts antibacterial activity against many Gram-positive and Gram-negative bacteria. Furthermore, the anti-inflammatory effects of ciclopirox have been demonstrated in human polymorphonuclear cells, where ciclopirox has inhibited the synthesis of prostaglandin and leukotriene. Ciclopirox can also exhibit its anti-inflammatory effects by inhibiting the formation of 5-lipoxygenase and cyclooxygenase.
Ciclopirox Absorption
Rapidly absorbed after oral administration. Mean absorption of ciclopirox after application to nails of all twenty digits and adjacent 5 millimeters of skin once daily for 6 months in patients with dermatophytic onychomycoses was less than 5% of the applied dose. Ciclopirox olamine also penetrates into hair and through the epidermis and hair follicles into sebaceous glands and dermis.
Ciclopirox side effects and Toxicity
Oral LD50 in rat is >10 ml/kg. Symptoms of overexposure include drowsiness and headache.
Ciclopirox Patient Information
No information avaliable
Ciclopirox Organisms Affected
Humans, other mammals, yeast and other fungi
