Ciclopirox en es it fr

Ciclopirox Brand names, Ciclopirox Analogs

Ciclopirox Brand Names Mixture

  • No information avaliable

Ciclopirox Chemical_Formula


Ciclopirox RX_link

Ciclopirox fda sheet

Ciclopirox FDA

Ciclopirox msds (material safety sheet)

Ciclopirox MSDS

Ciclopirox Synthesis Reference

No information avaliable

Ciclopirox Molecular Weight

207.269 g/mol

Ciclopirox Melting Point

144 oC

Ciclopirox H2O Solubility

No information avaliable

Ciclopirox State


Ciclopirox LogP


Ciclopirox Dosage Forms

Topical solution (8%)

Ciclopirox Indication

Used as a topical treatment in immunocompetent patients with mild to moderate onychomycosis of fingernails and toenails without lunula involvement, due to Trichophyton rubrum.

Ciclopirox Pharmacology

Ciclopirox is a broad-spectrum antifungal medication that also has antibacterial and anti-inflammatory properties. Its main mode of action is thought to be its high affinity for trivalent cations, which inhibit essential co-factors in enzymes. Ciclopirox exhibits either fungistatic or fungicidal activity in vitro against a broad spectrum of fungal organisms, such as dermatophytes, yeasts, dimorphic fungi, eumycetes, and actinomycetes. In addition to its broad spectrum of action, ciclopirox also exerts antibacterial activity against many Gram-positive and Gram-negative bacteria. Furthermore, the anti-inflammatory effects of ciclopirox have been demonstrated in human polymorphonuclear cells, where ciclopirox has inhibited the synthesis of prostaglandin and leukotriene. Ciclopirox can also exhibit its anti-inflammatory effects by inhibiting the formation of 5-lipoxygenase and cyclooxygenase.

Ciclopirox Absorption

Rapidly absorbed after oral administration. Mean absorption of ciclopirox after application to nails of all twenty digits and adjacent 5 millimeters of skin once daily for 6 months in patients with dermatophytic onychomycoses was less than 5% of the applied dose. Ciclopirox olamine also penetrates into hair and through the epidermis and hair follicles into sebaceous glands and dermis.

Ciclopirox side effects and Toxicity

Oral LD50 in rat is >10 ml/kg. Symptoms of overexposure include drowsiness and headache.

Ciclopirox Patient Information

No information avaliable

Ciclopirox Organisms Affected

Humans, other mammals, yeast and other fungi