Cerivastatin, sodium salt
Brand names,
Cerivastatin, sodium salt
Analogs
Cerivastatin, sodium salt
Brand Names Mixture
Cerivastatin, sodium salt
Chemical_Formula
C26H34FNO5
Cerivastatin, sodium salt
RX_link
http://www.rxlist.com/cgi/generic2/cerivastat.htm
Cerivastatin, sodium salt
fda sheet
Cerivastatin, sodium salt
msds (material safety sheet)
Cerivastatin, sodium salt
Synthesis Reference
Angerbauer R, Bischoff H, Steinke W and Ritter W (1994) BAY w 6228. Drugs Fut 19: 537-541.
Cerivastatin, sodium salt
Molecular Weight
459.55 g/mol
Cerivastatin, sodium salt
Melting Point
No information avaliable
Cerivastatin, sodium salt
H2O Solubility
Highly solubility
Cerivastatin, sodium salt
State
Solid
Cerivastatin, sodium salt
LogP
4.669
Cerivastatin, sodium salt
Dosage Forms
Tablet
Cerivastatin, sodium salt
Indication
Used as an adjunct to diet for the reduction of elevated total and LDL cholesterol levels in patients with primary hypercholesterolemia and mixed dyslipidemia (Fredrickson Types IIa and IIb) when the response to dietary restriction of saturated fat and cholesterol and other non-pharmacological measures alone has been inadequate.
Cerivastatin, sodium salt
Pharmacology
Cerivastatin, a competitive HMG-CoA reductase inhibitor effective in lowering LDL cholesterol and triglycerides, is used to treat primary hypercholesterolemia and mixed dyslipidemia (Fredrickson types IIa and IIb).
Cerivastatin, sodium salt
Absorption
The mean absolute oral bioavailability 60% (range 39 - 101%).
Cerivastatin, sodium salt
side effects and Toxicity
Rhabdomyolysis, liver concerns
Cerivastatin, sodium salt
Patient Information
Patients should be advised to report promptly unexplained muscle pain, tenderness, or weakness, particularly if
accompanied by malaise or fever.
Cerivastatin, sodium salt
Organisms Affected
Humans and other mammals