Baycol
Brand names,
Baycol
Analogs
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Brand Names Mixture
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Chemical_Formula
C26H34FNO5
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RX_link
http://www.rxlist.com/cgi/generic2/cerivastat.htm
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fda sheet
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msds (material safety sheet)
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Synthesis Reference
Angerbauer R, Bischoff H, Steinke W and Ritter W (1994) BAY w 6228. Drugs Fut 19: 537-541.
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Molecular Weight
459.55 g/mol
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Melting Point
No information avaliable
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H2O Solubility
Highly solubility
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State
Solid
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LogP
4.669
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Dosage Forms
Tablet
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Indication
Used as an adjunct to diet for the reduction of elevated total and LDL cholesterol levels in patients with primary hypercholesterolemia and mixed dyslipidemia (Fredrickson Types IIa and IIb) when the response to dietary restriction of saturated fat and cholesterol and other non-pharmacological measures alone has been inadequate.
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Pharmacology
Cerivastatin, a competitive HMG-CoA reductase inhibitor effective in lowering LDL cholesterol and triglycerides, is used to treat primary hypercholesterolemia and mixed dyslipidemia (Fredrickson types IIa and IIb).
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Absorption
The mean absolute oral bioavailability 60% (range 39 - 101%).
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side effects and Toxicity
Rhabdomyolysis, liver concerns
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Patient Information
Patients should be advised to report promptly unexplained muscle pain, tenderness, or weakness, particularly if
accompanied by malaise or fever.
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Organisms Affected
Humans and other mammals