Cefotaxime
Cefotaxime Brand names, Cefotaxime Analogs
Cefotaxime Brand Names Mixture
- No information avaliable
Cefotaxime Chemical_Formula
C16H17N5O7S2
Cefotaxime RX_link
http://www.rxlist.com/cgi/generic/cefotax.htm
Cefotaxime fda sheet
Cefotaxime msds (material safety sheet)
Cefotaxime Synthesis Reference
No information avaliable
Cefotaxime Molecular Weight
455.468 g/mol
Cefotaxime Melting Point
No information avaliable
Cefotaxime H2O Solubility
Soluble
Cefotaxime State
Solid
Cefotaxime LogP
-0.685
Cefotaxime Dosage Forms
Injection and infusion
Cefotaxime Indication
Used to treat gonorrhoea, meningitis, and severe infections including infections of the kidney (pyelonephritis) and urinary system. Also used before an operation to prevent infection after surgery.
Cefotaxime Pharmacology
Cefotaxime is a third generation intravenous cephalosporin antibiotic. It has broad spectrum activity against Gram positive and Gram negative bacteria. It does not have activity against Pseudomonas aeruginosa. Cefotaxime works by inhibiting bacterial cell wall biosynthesis. A positive feature of cefotaxime is that it display a resistance to penicillinases and is useful to treat infections that are resistant to penicillin derivatives.
Cefotaxime Absorption
Rapidly absorbed following intramuscular injection.
Cefotaxime side effects and Toxicity
Adverse effects following overdosage include nausea, vomiting, epigastric distress, diarrhea, and convulsions. Oral rat LD50 is over 20,000 mg/kg while intravenous rat LD50 is over 7,000 mg/kg.
Cefotaxime Patient Information
No information avaliable
Cefotaxime Organisms Affected
Enteric bacteria and other eubacteria
