Carvedilol
Carvedilol Brand names, Carvedilol Analogs
Carvedilol Brand Names Mixture
- No information avaliable
Carvedilol Chemical_Formula
C24H26N2O4
Carvedilol RX_link
http://www.rxlist.com/cgi/generic3/carvedilol.htm
Carvedilol fda sheet
Carvedilol msds (material safety sheet)
Carvedilol Synthesis Reference
No information avaliable
Carvedilol Molecular Weight
406.474 g/mol
Carvedilol Melting Point
114-115 oC
Carvedilol H2O Solubility
Practically insoluble (0.583 mg/L)
Carvedilol State
Solid
Carvedilol LogP
3.967
Carvedilol Dosage Forms
Tablet
Carvedilol Indication
For the treatment of mild or moderate (NYHA class II or III) heart failure of ischemic or cardiomyopathic origin.
Carvedilol Pharmacology
Carvedilol is a nonselective beta-adrenergic blocking agent with alpha1-blocking activity and is indicated for the treatment of hypertension and mild or moderate (NYHA class II or III) heart failure of ischemic or cardiomyopathic origin. Carvedilol is a racemic mixture in which nonselective b-adrenoreceptor blocking activity is present in the S(-) enantiomer and a-adrenergic blocking activity is present in both R(+) and S(-) enantiomers at equal potency. Carvedilol has no intrinsic sympathomimetic activity. The effect of carvedilol's b-adrenoreceptor blocking activity has been demonstrated in animal and human studies showing that carvedilol (1) reduces cardiac output in normal subjects; (2) reduces exercise-and/or isoproterenol-induced tachycardia and (3) reduces reflex orthostatic tachycardia.
Carvedilol Absorption
Carvedilol is rapidly and extensively absorbed following oral administration, with an absolute bioavailability of approximately 25% to 35% due to a significant degree of first-pass metabolism.
Carvedilol side effects and Toxicity
Not expected to be toxic following ingestion.
Carvedilol Patient Information
Patients taking COREG (Carvedilol) should be advised of the following:
- they should not interrupt or discontinue using COREG without a physician's advice.
- congestive heart failure patients should consult their physician if they experience signs or symptoms of worsening heart failure such as weight gain or increasing shortness of breath.
- they may experience a drop in blood pressure when standing, resulting in dizziness and, rarely, fainting. Patients should sit or lie down when these symptoms of lowered blood pressure occur.
- if patients experience dizziness or fatigue, they should avoid driving or hazardous tasks.
- they should consult a physician if they experience dizziness or faintness, in case the dosage should be adjusted.
- they should take COREG with food.
- diabetic patients should report any changes in blood sugar levels to their physician.
- contact lens wearers may experience decreased lacrimation.
Carvedilol Organisms Affected
Humans and other mammals
