Carvedilolum [Latin]

• Vasodilator Agents
• Antihypertensive Agents
• Adrenergic Agents
• ATC:C07AG02

• Carvedilol [Usan:Ban:Inn:Jan]
• Carvedilolum [Latin]
• Coreg

• No information avaliable

C₂₄H₂₆N₂O₄

http://www.rxlist.com/cgi/generic3/carvedilol.htm

Carvedilolum_[Latin] FDA

Carvedilolum_[Latin] MSDS

No information avaliable

406.474 g/mol

114-115 ^oC

Practically insoluble (0.583 mg/L)

Solid

3.967

Tablet

For the treatment of mild or moderate (NYHA class II or III) heart failure of ischemic or cardiomyopathic origin.

Carvedilol is a nonselective beta-adrenergic blocking agent with alpha1-blocking activity and is indicated for the treatment of hypertension and mild or moderate (NYHA class II or III) heart failure of ischemic or cardiomyopathic origin. Carvedilol is a racemic mixture in which nonselective b-adrenoreceptor blocking activity is present in the S(-) enantiomer and a-adrenergic blocking activity is present in both R(+) and S(-) enantiomers at equal potency. Carvedilol has no intrinsic sympathomimetic activity. The effect of carvedilol's b-adrenoreceptor blocking activity has been demonstrated in animal and human studies showing that carvedilol (1) reduces cardiac output in normal subjects; (2) reduces exercise-and/or isoproterenol-induced tachycardia and (3) reduces reflex orthostatic tachycardia.

Carvedilol is rapidly and extensively absorbed following oral administration, with an absolute bioavailability of approximately 25% to 35% due to a significant degree of first-pass metabolism.

Not expected to be toxic following ingestion.

Patients taking COREG (Carvedilol) should be advised of the following:

• they should not interrupt or discontinue using COREG without a physician's advice.
• congestive heart failure patients should consult their physician if they experience signs or symptoms of worsening heart failure such as weight gain or increasing shortness of breath.
• they may experience a drop in blood pressure when standing, resulting in dizziness and, rarely, fainting. Patients should sit or lie down when these symptoms of lowered blood pressure occur.
• if patients experience dizziness or fatigue, they should avoid driving or hazardous tasks.
• they should consult a physician if they experience dizziness or faintness, in case the dosage should be adjusted.
• they should take COREG with food.
• diabetic patients should report any changes in blood sugar levels to their physician.
• contact lens wearers may experience decreased lacrimation.

Humans and other mammals