BoNT/A
BoNT/A Brand names, BoNT/A Analogs
BoNT/A Brand Names Mixture
- No information avaliable
BoNT/A Chemical_Formula
C6760H10447N1743O2010S32
BoNT/A RX_link
http://www.rxlist.com/cgi/generic2/botulinumtoxin.htm
BoNT/A fda sheet
BoNT/A msds (material safety sheet)
BoNT/A Synthesis Reference
No information avaliable
BoNT/A Molecular Weight
149322.7
BoNT/A Melting Point
No information avaliable
BoNT/A H2O Solubility
No information avaliable
BoNT/A State
Liquid
BoNT/A LogP
-0.368
BoNT/A Dosage Forms
Solution
BoNT/A Indication
For treatment of cervical dystonia, axillary hyperhidrosis, strabismus, facial wrinkles
BoNT/A Pharmacology
Myobloc inhibits acetylcholine release at the neuromuscular junction via a three stage process: 1) Heavy Chain mediated neurospecific binding of the toxin, 2) internalization of the toxin by receptor-mediated endocytosis, and 3) ATP and pH dependent translocation of the Light Chain to the neuronal cytosol where it acts as a zinc-dependent endoprotease cleaving polypeptides essential for neurotransmitter release.
BoNT/A Absorption
No information avaliable
BoNT/A side effects and Toxicity
No information avaliable
BoNT/A Patient Information
No information avaliable
BoNT/A Organisms Affected
Humans and other mammals
