Bleomicina [INN-Spanish] en es it fr

Bleomicina [INN-Spanish] Brand names, Bleomicina [INN-Spanish] Analogs

Bleomicina [INN-Spanish] Brand Names Mixture

  • No information avaliable

Bleomicina [INN-Spanish] Chemical_Formula


Bleomicina [INN-Spanish] RX_link

Bleomicina [INN-Spanish] fda sheet

Bleomicina [INN-Spanish] msds (material safety sheet)

Bleomicina_[INN-Spanish] MSDS

Bleomicina [INN-Spanish] Synthesis Reference

T. Takita et al., ibid. 254

Bleomicina [INN-Spanish] Molecular Weight

1415.56 g/mol

Bleomicina [INN-Spanish] Melting Point

71 oC

Bleomicina [INN-Spanish] H2O Solubility


Bleomicina [INN-Spanish] State


Bleomicina [INN-Spanish] LogP

No information avaliable

Bleomicina [INN-Spanish] Dosage Forms

Injection; Powder for solution

Bleomicina [INN-Spanish] Indication

For palliative treatment in the management malignant neoplasm (trachea, bronchus, lung), squamous cell carcinoma, and lymphomas.

Bleomicina [INN-Spanish] Pharmacology

Bleomycin is an antibiotic which has been shown to have antitumor activity. Bleomycin selectively inhibits the synthesis of deoxyribonucleic acid (DNA). The guanine and cytosine content correlates with the degree of mitomycin-induced cross-linking. At high concentrations of the drug, cellular RNA and protein synthesis are also suppressed. Bleomycin has been shown in vitro to inhibit B cell, T cell, and macrophage proliferation and impair antigen presentation, as well as the secretion of interferon gamma, TNFa, and IL-2. The antibiotic antitumor drugs are cell cycle-nonspecific except for Bleomycin (which has major effects in G2 and M phases).

Bleomicina [INN-Spanish] Absorption

Systemic absorption is approximately 45%.

Bleomicina [INN-Spanish] side effects and Toxicity

Excessive exposure may cause fever, chills, nausea, vomiting, mental, confusion, and wheezing. Bleomycin may cause irritation to eyes, skin and respiratory tract. It may also cause a darkening or thickening of the skin. It may cause an allergic reaction.

Bleomicina [INN-Spanish] Patient Information

Bleomycin should only be administered under the supervision of a qualified
healthcare provider experienced in the use of cancer chemotherapeutic agents.
Serious side effects have been reported with the use of bleomycin including: allergic
reactions (difficulty breathing; closing of the throat; swelling of the lips, tongue,
or face; or hives); a severe reaction consisting of low blood pressure, mental confusion,
fever, chills, and wheezing; pulmonary fibrosis (a lung condition); and others. Talk to
your doctor about the possible side effects from treatment with bleomycin.

Bleomicina [INN-Spanish] Organisms Affected

Humans and other mammals