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BLM Brand names, BLM Analogs

BLM Brand Names Mixture

  • No information avaliable

BLM Chemical_Formula


BLM RX_link

BLM fda sheet

BLM msds (material safety sheet)


BLM Synthesis Reference

T. Takita et al., ibid. 254

BLM Molecular Weight

1415.56 g/mol

BLM Melting Point

71 oC

BLM H2O Solubility


BLM State



No information avaliable

BLM Dosage Forms

Injection; Powder for solution

BLM Indication

For palliative treatment in the management malignant neoplasm (trachea, bronchus, lung), squamous cell carcinoma, and lymphomas.

BLM Pharmacology

Bleomycin is an antibiotic which has been shown to have antitumor activity. Bleomycin selectively inhibits the synthesis of deoxyribonucleic acid (DNA). The guanine and cytosine content correlates with the degree of mitomycin-induced cross-linking. At high concentrations of the drug, cellular RNA and protein synthesis are also suppressed. Bleomycin has been shown in vitro to inhibit B cell, T cell, and macrophage proliferation and impair antigen presentation, as well as the secretion of interferon gamma, TNFa, and IL-2. The antibiotic antitumor drugs are cell cycle-nonspecific except for Bleomycin (which has major effects in G2 and M phases).

BLM Absorption

Systemic absorption is approximately 45%.

BLM side effects and Toxicity

Excessive exposure may cause fever, chills, nausea, vomiting, mental, confusion, and wheezing. Bleomycin may cause irritation to eyes, skin and respiratory tract. It may also cause a darkening or thickening of the skin. It may cause an allergic reaction.

BLM Patient Information

Bleomycin should only be administered under the supervision of a qualified
healthcare provider experienced in the use of cancer chemotherapeutic agents.
Serious side effects have been reported with the use of bleomycin including: allergic
reactions (difficulty breathing; closing of the throat; swelling of the lips, tongue,
or face; or hives); a severe reaction consisting of low blood pressure, mental confusion,
fever, chills, and wheezing; pulmonary fibrosis (a lung condition); and others. Talk to
your doctor about the possible side effects from treatment with bleomycin.

BLM Organisms Affected

Humans and other mammals