BLM
BLM Brand names, BLM Analogs
BLM Brand Names Mixture
- No information avaliable
BLM Chemical_Formula
C55H84N17O21S3
BLM RX_link
http://www.rxlist.com/cgi/generic3/bleomycin.htm
BLM fda sheet
BLM msds (material safety sheet)
BLM Synthesis Reference
T. Takita et al., ibid. 254
BLM Molecular Weight
1415.56 g/mol
BLM Melting Point
71 oC
BLM H2O Solubility
Soluble
BLM State
Solid
BLM LogP
No information avaliable
BLM Dosage Forms
Injection; Powder for solution
BLM Indication
For palliative treatment in the management malignant neoplasm (trachea, bronchus, lung), squamous cell carcinoma, and lymphomas.
BLM Pharmacology
Bleomycin is an antibiotic which has been shown to have antitumor activity. Bleomycin selectively inhibits the synthesis of deoxyribonucleic acid (DNA). The guanine and cytosine content correlates with the degree of mitomycin-induced cross-linking. At high concentrations of the drug, cellular RNA and protein synthesis are also suppressed. Bleomycin has been shown in vitro to inhibit B cell, T cell, and macrophage proliferation and impair antigen presentation, as well as the secretion of interferon gamma, TNFa, and IL-2. The antibiotic antitumor drugs are cell cycle-nonspecific except for Bleomycin (which has major effects in G2 and M phases).
BLM Absorption
Systemic absorption is approximately 45%.
BLM side effects and Toxicity
Excessive exposure may cause fever, chills, nausea, vomiting, mental, confusion, and wheezing. Bleomycin may cause irritation to eyes, skin and respiratory tract. It may also cause a darkening or thickening of the skin. It may cause an allergic reaction.
BLM Patient Information
Bleomycin should only be administered under the supervision of a qualified
healthcare provider experienced in the use of cancer chemotherapeutic agents.
Serious side effects have been reported with the use of bleomycin including: allergic
reactions (difficulty breathing; closing of the throat; swelling of the lips, tongue,
or face; or hives); a severe reaction consisting of low blood pressure, mental confusion,
fever, chills, and wheezing; pulmonary fibrosis (a lung condition); and others. Talk to
your doctor about the possible side effects from treatment with bleomycin.
healthcare provider experienced in the use of cancer chemotherapeutic agents.
Serious side effects have been reported with the use of bleomycin including: allergic
reactions (difficulty breathing; closing of the throat; swelling of the lips, tongue,
or face; or hives); a severe reaction consisting of low blood pressure, mental confusion,
fever, chills, and wheezing; pulmonary fibrosis (a lung condition); and others. Talk to
your doctor about the possible side effects from treatment with bleomycin.
BLM Organisms Affected
Humans and other mammals
