Bleo
Bleo Brand names, Bleo Analogs
Bleo Brand Names Mixture
- No information avaliable
Bleo Chemical_Formula
C55H84N17O21S3
Bleo RX_link
http://www.rxlist.com/cgi/generic3/bleomycin.htm
Bleo fda sheet
Bleo msds (material safety sheet)
Bleo Synthesis Reference
T. Takita et al., ibid. 254
Bleo Molecular Weight
1415.56 g/mol
Bleo Melting Point
71 oC
Bleo H2O Solubility
Soluble
Bleo State
Solid
Bleo LogP
No information avaliable
Bleo Dosage Forms
Injection; Powder for solution
Bleo Indication
For palliative treatment in the management malignant neoplasm (trachea, bronchus, lung), squamous cell carcinoma, and lymphomas.
Bleo Pharmacology
Bleomycin is an antibiotic which has been shown to have antitumor activity. Bleomycin selectively inhibits the synthesis of deoxyribonucleic acid (DNA). The guanine and cytosine content correlates with the degree of mitomycin-induced cross-linking. At high concentrations of the drug, cellular RNA and protein synthesis are also suppressed. Bleomycin has been shown in vitro to inhibit B cell, T cell, and macrophage proliferation and impair antigen presentation, as well as the secretion of interferon gamma, TNFa, and IL-2. The antibiotic antitumor drugs are cell cycle-nonspecific except for Bleomycin (which has major effects in G2 and M phases).
Bleo Absorption
Systemic absorption is approximately 45%.
Bleo side effects and Toxicity
Excessive exposure may cause fever, chills, nausea, vomiting, mental, confusion, and wheezing. Bleomycin may cause irritation to eyes, skin and respiratory tract. It may also cause a darkening or thickening of the skin. It may cause an allergic reaction.
Bleo Patient Information
Bleomycin should only be administered under the supervision of a qualified
healthcare provider experienced in the use of cancer chemotherapeutic agents.
Serious side effects have been reported with the use of bleomycin including: allergic
reactions (difficulty breathing; closing of the throat; swelling of the lips, tongue,
or face; or hives); a severe reaction consisting of low blood pressure, mental confusion,
fever, chills, and wheezing; pulmonary fibrosis (a lung condition); and others. Talk to
your doctor about the possible side effects from treatment with bleomycin.
healthcare provider experienced in the use of cancer chemotherapeutic agents.
Serious side effects have been reported with the use of bleomycin including: allergic
reactions (difficulty breathing; closing of the throat; swelling of the lips, tongue,
or face; or hives); a severe reaction consisting of low blood pressure, mental confusion,
fever, chills, and wheezing; pulmonary fibrosis (a lung condition); and others. Talk to
your doctor about the possible side effects from treatment with bleomycin.
Bleo Organisms Affected
Humans and other mammals
