Blenoxane
Blenoxane Brand names, Blenoxane Analogs
Blenoxane Brand Names Mixture
- No information avaliable
Blenoxane Chemical_Formula
C55H84N17O21S3
Blenoxane RX_link
http://www.rxlist.com/cgi/generic3/bleomycin.htm
Blenoxane fda sheet
Blenoxane msds (material safety sheet)
Blenoxane Synthesis Reference
T. Takita et al., ibid. 254
Blenoxane Molecular Weight
1415.56 g/mol
Blenoxane Melting Point
71 oC
Blenoxane H2O Solubility
Soluble
Blenoxane State
Solid
Blenoxane LogP
No information avaliable
Blenoxane Dosage Forms
Injection; Powder for solution
Blenoxane Indication
For palliative treatment in the management malignant neoplasm (trachea, bronchus, lung), squamous cell carcinoma, and lymphomas.
Blenoxane Pharmacology
Bleomycin is an antibiotic which has been shown to have antitumor activity. Bleomycin selectively inhibits the synthesis of deoxyribonucleic acid (DNA). The guanine and cytosine content correlates with the degree of mitomycin-induced cross-linking. At high concentrations of the drug, cellular RNA and protein synthesis are also suppressed. Bleomycin has been shown in vitro to inhibit B cell, T cell, and macrophage proliferation and impair antigen presentation, as well as the secretion of interferon gamma, TNFa, and IL-2. The antibiotic antitumor drugs are cell cycle-nonspecific except for Bleomycin (which has major effects in G2 and M phases).
Blenoxane Absorption
Systemic absorption is approximately 45%.
Blenoxane side effects and Toxicity
Excessive exposure may cause fever, chills, nausea, vomiting, mental, confusion, and wheezing. Bleomycin may cause irritation to eyes, skin and respiratory tract. It may also cause a darkening or thickening of the skin. It may cause an allergic reaction.
Blenoxane Patient Information
Bleomycin should only be administered under the supervision of a qualified
healthcare provider experienced in the use of cancer chemotherapeutic agents.
Serious side effects have been reported with the use of bleomycin including: allergic
reactions (difficulty breathing; closing of the throat; swelling of the lips, tongue,
or face; or hives); a severe reaction consisting of low blood pressure, mental confusion,
fever, chills, and wheezing; pulmonary fibrosis (a lung condition); and others. Talk to
your doctor about the possible side effects from treatment with bleomycin.
healthcare provider experienced in the use of cancer chemotherapeutic agents.
Serious side effects have been reported with the use of bleomycin including: allergic
reactions (difficulty breathing; closing of the throat; swelling of the lips, tongue,
or face; or hives); a severe reaction consisting of low blood pressure, mental confusion,
fever, chills, and wheezing; pulmonary fibrosis (a lung condition); and others. Talk to
your doctor about the possible side effects from treatment with bleomycin.
Blenoxane Organisms Affected
Humans and other mammals
