Bevacizumab
Brand names,
Bevacizumab
Analogs
Bevacizumab
Brand Names Mixture
Bevacizumab
Chemical_Formula
No information avaliable
Bevacizumab
RX_link
http://www.rxlist.com/cgi/generic3/avastin.htm
Bevacizumab
fda sheet
Bevacizumab
msds (material safety sheet)
Bevacizumab
Synthesis Reference
sequence listed in Presta LG, Chen H, O'Connor SJ, et al Humanization of an anti-vascular endothelial growth factor monoclonal antibody for the therapy of solid tumors and other disorders. Cancer Res, 57: 4593-9, 1997
Bevacizumab
Molecular Weight
No information avaliable
Bevacizumab
Melting Point
61 oC (FAB fragment), 71 oC (whole mAb) - Vermeer, A.W.P. & Norde, W., Biophys. J. 78:394-404 (2000).
Bevacizumab
H2O Solubility
No information avaliable
Bevacizumab
State
Liquid
Bevacizumab
LogP
No information avaliable
Bevacizumab
Dosage Forms
Solution (IV Infusion)
Bevacizumab
Indication
For treatment of metastatic colorectal cancer
Bevacizumab
Pharmacology
Bevacizumab prevents or reduces the formation of blood vessels (angiogenesis) thereby preventing or reducing metatstatic disease progressing. Bevacizumab binds VEGF and prevents vascular endothelial growth and endothelial cell proliferation.
Bevacizumab
Absorption
No information avaliable
Bevacizumab
side effects and Toxicity
No information avaliable
Bevacizumab
Patient Information
No information avaliable
Bevacizumab
Organisms Affected
Humans and other mammals