Avastin
Brand names,
Avastin
Analogs
Avastin
Brand Names Mixture
Avastin
Chemical_Formula
No information avaliable
Avastin
RX_link
http://www.rxlist.com/cgi/generic3/avastin.htm
Avastin
fda sheet
Avastin
msds (material safety sheet)
Avastin
Synthesis Reference
sequence listed in Presta LG, Chen H, O'Connor SJ, et al Humanization of an anti-vascular endothelial growth factor monoclonal antibody for the therapy of solid tumors and other disorders. Cancer Res, 57: 4593-9, 1997
Avastin
Molecular Weight
No information avaliable
Avastin
Melting Point
61 oC (FAB fragment), 71 oC (whole mAb) - Vermeer, A.W.P. & Norde, W., Biophys. J. 78:394-404 (2000).
Avastin
H2O Solubility
No information avaliable
Avastin
State
Liquid
Avastin
LogP
No information avaliable
Avastin
Dosage Forms
Solution (IV Infusion)
Avastin
Indication
For treatment of metastatic colorectal cancer
Avastin
Pharmacology
Bevacizumab prevents or reduces the formation of blood vessels (angiogenesis) thereby preventing or reducing metatstatic disease progressing. Bevacizumab binds VEGF and prevents vascular endothelial growth and endothelial cell proliferation.
Avastin
Absorption
No information avaliable
Avastin
side effects and Toxicity
No information avaliable
Avastin
Patient Information
No information avaliable
Avastin
Organisms Affected
Humans and other mammals