Baclofen
Baclofen Brand names, Baclofen Analogs
Baclofen Brand Names Mixture
- No information avaliable
Baclofen Chemical_Formula
C10H12ClNO2
Baclofen RX_link
http://www.rxlist.com/cgi/generic/baclofen.htm
Baclofen fda sheet
Baclofen msds (material safety sheet)
Baclofen Synthesis Reference
Neth. pat. Appl. 6,407,755; H. Keberle et al., U.S. pat. 3,471,548 (1965, 1969 both to Ciba)
Baclofen Molecular Weight
213.661 g/mol
Baclofen Melting Point
206-208 oC
Baclofen H2O Solubility
2090 mg/L
Baclofen State
Solid
Baclofen LogP
1.42
Baclofen Dosage Forms
Tablet; Intrathecal injection
Baclofen Indication
For the alleviation of signs and symptoms of spasticity resulting from multiple sclerosis, particularly for the relief of flexor spasms and concomitant pain, clonus, and muscular rigidity
Baclofen Pharmacology
Baclofen is a muscle relaxant and antispastic. Baclofen is useful for the alleviation of signs and symptoms of spasticity resulting from multiple sclerosis, particularly for the relief of flexor spasms and concomitant pain, clonus, and muscular rigidity. Although Baclofen is an analog of the putative inhibitory neurotransmitter gamma-aminobutyric acid (GABA), there is no conclusive evidence that actions on GABA systems are involved in the production of its clinical effects. In studies with animals, Baclofen has been shown to have general CNS depressant properties as indicated by the production of sedation with tolerance, somnolence, ataxia, and respiratory and cardiovascular depression. Baclofen is rapidly and extensively absorbed and eliminated. Absorption may be dose-dependent, being reduced with increasing doses. Baclofen is excreted primarily by the kidney in unchanged form and there is relatively large intersubject variation in absorption and/or elimination.
Baclofen Absorption
Rapidly and extensively absorbed
Baclofen side effects and Toxicity
LD50=45 mg/kg (male mice, IV); LD50=78 mg/kg (male rat, IV)
Baclofen Patient Information
Baclofen Organisms Affected
Humans and other mammals
