Lioresal Intrathecal en es it fr

Lioresal Intrathecal Brand names, Lioresal Intrathecal Analogs

Lioresal Intrathecal Brand Names Mixture

  • No information avaliable

Lioresal Intrathecal Chemical_Formula

C10H12ClNO2

Lioresal Intrathecal RX_link

http://www.rxlist.com/cgi/generic/baclofen.htm

Lioresal Intrathecal fda sheet

Lioresal_Intrathecal FDA

Lioresal Intrathecal msds (material safety sheet)

Lioresal Intrathecal Synthesis Reference

Neth. pat. Appl. 6,407,755; H. Keberle et al., U.S. pat. 3,471,548 (1965, 1969 both to Ciba)

Lioresal Intrathecal Molecular Weight

213.661 g/mol

Lioresal Intrathecal Melting Point

206-208 oC

Lioresal Intrathecal H2O Solubility

2090 mg/L

Lioresal Intrathecal State

Solid

Lioresal Intrathecal LogP

1.42

Lioresal Intrathecal Dosage Forms

Tablet; Intrathecal injection

Lioresal Intrathecal Indication

For the alleviation of signs and symptoms of spasticity resulting from multiple sclerosis, particularly for the relief of flexor spasms and concomitant pain, clonus, and muscular rigidity

Lioresal Intrathecal Pharmacology

Baclofen is a muscle relaxant and antispastic. Baclofen is useful for the alleviation of signs and symptoms of spasticity resulting from multiple sclerosis, particularly for the relief of flexor spasms and concomitant pain, clonus, and muscular rigidity. Although Baclofen is an analog of the putative inhibitory neurotransmitter gamma-aminobutyric acid (GABA), there is no conclusive evidence that actions on GABA systems are involved in the production of its clinical effects. In studies with animals, Baclofen has been shown to have general CNS depressant properties as indicated by the production of sedation with tolerance, somnolence, ataxia, and respiratory and cardiovascular depression. Baclofen is rapidly and extensively absorbed and eliminated. Absorption may be dose-dependent, being reduced with increasing doses. Baclofen is excreted primarily by the kidney in unchanged form and there is relatively large intersubject variation in absorption and/or elimination.

Lioresal Intrathecal Absorption

Rapidly and extensively absorbed

Lioresal Intrathecal side effects and Toxicity

LD50=45 mg/kg (male mice, IV); LD50=78 mg/kg (male rat, IV)

Lioresal Intrathecal Patient Information

Lioresal Intrathecal Organisms Affected

Humans and other mammals