Lioresal Intrathecal
Lioresal Intrathecal Brand names, Lioresal Intrathecal Analogs
Lioresal Intrathecal Brand Names Mixture
- No information avaliable
Lioresal Intrathecal Chemical_Formula
C10H12ClNO2
Lioresal Intrathecal RX_link
http://www.rxlist.com/cgi/generic/baclofen.htm
Lioresal Intrathecal fda sheet
Lioresal Intrathecal msds (material safety sheet)
Lioresal Intrathecal Synthesis Reference
Neth. pat. Appl. 6,407,755; H. Keberle et al., U.S. pat. 3,471,548 (1965, 1969 both to Ciba)
Lioresal Intrathecal Molecular Weight
213.661 g/mol
Lioresal Intrathecal Melting Point
206-208 oC
Lioresal Intrathecal H2O Solubility
2090 mg/L
Lioresal Intrathecal State
Solid
Lioresal Intrathecal LogP
1.42
Lioresal Intrathecal Dosage Forms
Tablet; Intrathecal injection
Lioresal Intrathecal Indication
For the alleviation of signs and symptoms of spasticity resulting from multiple sclerosis, particularly for the relief of flexor spasms and concomitant pain, clonus, and muscular rigidity
Lioresal Intrathecal Pharmacology
Baclofen is a muscle relaxant and antispastic. Baclofen is useful for the alleviation of signs and symptoms of spasticity resulting from multiple sclerosis, particularly for the relief of flexor spasms and concomitant pain, clonus, and muscular rigidity. Although Baclofen is an analog of the putative inhibitory neurotransmitter gamma-aminobutyric acid (GABA), there is no conclusive evidence that actions on GABA systems are involved in the production of its clinical effects. In studies with animals, Baclofen has been shown to have general CNS depressant properties as indicated by the production of sedation with tolerance, somnolence, ataxia, and respiratory and cardiovascular depression. Baclofen is rapidly and extensively absorbed and eliminated. Absorption may be dose-dependent, being reduced with increasing doses. Baclofen is excreted primarily by the kidney in unchanged form and there is relatively large intersubject variation in absorption and/or elimination.
Lioresal Intrathecal Absorption
Rapidly and extensively absorbed
Lioresal Intrathecal side effects and Toxicity
LD50=45 mg/kg (male mice, IV); LD50=78 mg/kg (male rat, IV)
Lioresal Intrathecal Patient Information
Lioresal Intrathecal Organisms Affected
Humans and other mammals
